AI Article Synopsis
- The study assessed the effectiveness of indirect diode laser treatment for threshold retinopathy of prematurity (ROP) over a decade, finding that 86% of treated eyes experienced regression of neovascularization.
- It identified that infants with zone 1 disease had a higher progression rate to severe ROP stages compared to those with zone 2 disease, and that female gender and zone were predictors of disease progression.
- Over the ten years, there was a trend of premature infants being born at lower gestational ages and weights, but severity progression rates after treatment remained consistent, indicating that proper treatment can lead to positive outcomes for these infants.
Article Abstract
Purpose: To evaluate the outcome of indirect diode laser treatment for threshold retinopathy of prematurity (ROP) and to report demographic changes observed over 10 years.
Methods: Retrospective chart review and statistical analysis of 111 eyes of 61 infants treated for threshold ROP between 1991-2001 at a single academic institution.
Results: Ninety-six 111(86%) eyes showed regression of neovascularization after laser treatment. Fourteen (13%) eyes had zone 1 disease and 97 (87%) eyes had zone 2 disease. Thirty-six percent of eyes with zone 1 disease progressed to stage 4 or 5 disease despite treatment, whereas 10% of the zone 2 eyes progressed. Based on multivariate logistic regression, zone and female gender were found to be predictive of progression, whereas birth weight was predictive of zone. Between 1991 and 2001, a significant trend toward lower mean gestational age at time of birth (Pearson correlation = -0.35, P = .0041) was found. However, progression rates to stage 4 and 5 disease following laser treatment were similar for infants born before and after 1997 (P = .0796).
Conclusion: Regression of neovascularization was noted in 86% of eyes following laser treatment for threshold ROP. Zone was predictive of progression to stage 4 or 5 despite treatment. Premature infants being treated for threshold ROP tended to be born at an earlier gestational age and with lower birth weights over time, but progression rates to more severe stages did not increase following laser treatment, suggesting that optimal treatment can yield favorable ocular outcomes.
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| http://dx.doi.org/10.3928/01913913-20090918-08 | DOI Listing |
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