Discussed herein are priorities of appropriate application of a special instrumental examination of the arterial bed of the lower extremities in elderly and aged patients presenting with chronic critical ischaemia on the background ofatherosclerosis obliterans. Also analysed are the findings ofan ultrasonographic examination of the lower-limb arterial system as afundamental methodfor diagnosis of an atherosclerotic lesion thereoffollowed by comparing the findings of the preoperative examination with the intraoperative data obtained during revision of the femoropopliteal segment. The obtained results made it possible to formulate conclusions on the preferable use ofultrasonographyfor examining gerontological patients suffering from lower limb chronic critical ischaemia as a simple, rapid, informative, and most importantly, non-invasive method, which is extremely importantfor elderly and aged people. It is underlined that in a series of cases contrast-enhanced aortoangiography can be used for examining the vascular status in gerontological patients; however, preference should still be given to an ultrasonographic examination of the lower-limb arterial bed or even direct visualisation of the affected arterial segment during intraoperative revision thereof.
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Alzheimers Dement
December 2024
Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: The first disease-modifying treatments (DMTs) for Alzheimer's disease (AD) have been approved in the USA, marking profound changes in AD-diagnosis and treatment. This will bring new challenges in terms of clinician-patient communication. We aimed to collect the perspectives of memory clinic professionals regarding the most important topics to address and what (tools) would support professionals and their patients and care partners to engage in a meaningful conversation on whether (or not) to initiate treatment.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
In Japan, the regulatory authority approved the drug in September 2023, and on December 20, it became available for prescription country-wide under the health insurance system. However, there are strict patient, physician, and facility requirements for the prescription of Lecanemab, and various problems are anticipated in its future implementation and widespread use in society. Lecanemab is the first anti-Aβ antibody in Japan, and even dementia specialists do not have sufficient knowledge and experience in its introduction, evaluation of efficacy, and evaluation and handling of side effects.
View Article and Find Full Text PDFBackground: Dementia is a life-changing condition for patients and caregivers. Response to a diagnosis often includes grief, shock, and despair. Unfortunately, evidence demonstrates inadequate use of person-centered communication practices during diagnostic disclosure, which adds to psychological distress.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Center for Life Ethics, University of Bonn, Bonn, Germany.
Background: Driven by (bio-)medical and technical developments, advanced non-invasive methods for estimating the risk of Alzheimer's dementia (ADD) are increasingly emerging. In the future, such methods could eventually become available for individuals in asymptomatic and preclinical stages of Alzheimer's disease (e.g.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Background: To enhance the well-being of individuals with dementia, it is crucial to minimize the risk of deterioration in long-term care needs. This study aimed to identify factors and construct predictive models for deterioration in long-term care (LTC) levels in Japanese older adults with Mild Cognitive Impairment (MCI) and dementia.
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