Falls among the elderly population are a major cause of morbidity and injury-particularly among the over 65 years age group. Validated clinical tests and associated models, built upon assessment of functional ability, have been devised to estimate an individual's risk of falling in the near future. Those identified as at-risk of falling may be targeted for interventative treatment. The migration of these clinical models estimating falls risk to a surrogate technique, for use in the unsupervised environment, might broaden the reach of falls-risk screening beyond the clinical arena. This study details an approach that characterizes the movements of 68 elderly subjects performing a directed routine of unsupervised physical tasks. The movement characterization is achieved through the use of a triaxial accelerometer. A number of fall-related features, extracted from the accelerometry signals, combined with a linear least squares model, maps to a clinically validated measure of falls risk with a correlation of rho = 0.81 (p < 0.001).
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http://dx.doi.org/10.1109/TBME.2009.2033038 | DOI Listing |
JAMA Netw Open
January 2025
Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Importance: Multisystem inflammatory syndrome in children (MIS-C) is an uncommon but severe hyperinflammatory illness that occurs 2 to 6 weeks after SARS-CoV-2 infection. Presentation overlaps with other conditions, and risk factors for severity differ by patient. Characterizing patterns of MIS-C presentation can guide efforts to reduce misclassification, categorize phenotypes, and identify patients at risk for severe outcomes.
View Article and Find Full Text PDFFront Bioeng Biotechnol
January 2025
College of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Introduction: Aging-related deficits in the physiological properties of skeletal muscles limit the control of dynamic stability during walking. However, the specific causal relationships between these factors remain unclear. This study evaluated the effects of aging-related deficits in muscle properties on dynamic stability during walking.
View Article and Find Full Text PDFAging Clin Exp Res
January 2025
Department of Public Health and Community Programs, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal.
Introduction: Frailty, characterized by decreased resilience due to physiological decline, affects approximately 65% of community-dwelling elderly in Nepal. This study assessed frailty and its factors among hospitalized older adults in a tertiary hospital in Nepal.
Methods: This cross-sectional study included 124 participants aged 60 and above, admitted to a tertiary hospital in Nepal.
Int J Drug Policy
January 2025
MGH Institute for Technology Assessment, Harvard Medical School, Boston, MA, 02144, USA. Electronic address:
The overdose epidemic in the United States is evolving, with a rise in stimulant (cocaine and/or methamphetamine)-only and opioid and stimulant-involved overdose deaths for reasons that remain unclear. We conducted interviews and group model building workshops in Massachusetts and South Dakota. Building on these data and extant research, we identified six dynamic hypotheses, explaining changes in stimulant-involved overdose trends, visualized using causal loop diagrams.
View Article and Find Full Text PDFEur Geriatr Med
January 2025
Department of Gerontology, Lille University Hospital, Lille, France.
Methods: We conducted a single-center, retrospective cohort study of French older adults. Participants with Mini-Mental State Examination (MMSE) ≥ 24 were recruited from a fall clinic in a geriatrics department. We recorded history of falls in the preceding 6 months, as well as Timed Up and Go test and mobility assessment at baseline and at 6- and 12-month follow-up.
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