Aim: The aim of the study was to evaluate the current role of (123)I-MIBG scintigraphy in the detection and follow-up of patients with paragangliomas.
Materials And Methods: 117 patients were referred for diagnostic (123)I-MIBG scintigraphy based on a strong clinical suspicion, positive familial history and genetic testing, or for follow-up of paragangliomas.(123)I-MIBG images were analyzed and correlated with (111)In-octreotide scintigraphy, CT or MRI results. Accuracy of the imaging method was calculated per patient and per tumor per site.
Results: A total of 117 patients were referred for (123)I-MIBG diagnostic imaging; 80 patients were diagnosed with paraganglioma; 66 patients had a single neuroendocrine tumor and 14 patients multiple tumors. The total number of all lesions in these patients was 172. (123)I-MIBG scintigraphy demonstrated 65 lesions in 56 patients (overall sensitivity: 56.3%, specificity: 84%). Lesion-per-site analysis revealed that sensitivity and specificity significantly varied per tumor site (lowest sensitivity for the head and neck: 17.5% and lowest specificity for the abdomen: 87.5%). Hormones were elevated in 85 patients: 55 (123)I-MIBG tumors were positive and 35 tumors were negative. In 16 patients (13.7%) with a genetic burden and a single neuroendocrine tumor, (123)I-MIBG whole-body imaging was successful at detecting a second tumor. In 2 patients (1.7%) with paragangliomas, (123)I-MIBG unexpectedly detected metastases, so the restaging was properly done.
Conclusion: (123)I-MIBG scintigraphy remains important in pheochromocytoma and functioning neuroendocrine tumors. The value of (123)I-MIBG scintigraphy is high in familial syndromes with multiple neuroendocrine tumors at different sites, multifocal tumors, and relapsing and metastatic disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000242499 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[A Case of Retroperitoneal Abscess with Severe Inflammatory Adherence to Inferior Vena Cava].
Hinyokika Kiyo
August 2024
The Department of Renal and Urologic Surgery, Asahikawa Medical University.
We report a case of retroperitoneal abscess mimicking a malignant retroperitoneal tumor. A 77-yearold woman was referred to our hospital because of retroperitoneal tumor without any symptoms. The tumor was located just behind the inferior vena cava, and the tumor size was about 38 mm.
View Article and Find Full Text PDFRemote ischemic periconditioning suppresses cardiac sympathetic activation in acute myocardial infarction: a randomized controlled trial.
Eur J Nucl Med Mol Imaging
February 2025
Division of Cardiology, Osaka General Medical Center, Osaka, 558-8558, Japan.
Article Synopsis
- Remote ischemic periconditioning (RIPC) enhances cardioprotection and outcomes during urgent procedures in STEMI patients but its effects on cardiac sympathetic nerve activity were unclear.
- The study involved assigning STEMI patients to either RIPC or a control group during emergency PCI, measuring cardiac nerve activity via I-MIBG imaging.
- While initial discharge measurements showed no significant differences in cardiac sympathetic activity between groups, at a 1-year follow-up, the RIPC group exhibited lower sympathetic nerve activity and better imaging results in nonculprit lesions, indicating a lasting positive effect of RIPC.
Laparoscopic resection for retroperitoneum ganglioneuroma with Supine hypotension syndrome.
Surg Case Rep
August 2024
Department of Pathology, Shizuoka Children's Hospital, 860 Urushiyama, Aoi-Ku, Shizuoka, 420-8660, Japan.
Background: Supine hypotension syndrome (SHS) has been reported to occur due to compression by a giant tumor such as ovarian tumor. We herein report a case of retroperitoneal ganglioneuroma with SHS treated with laparoscopic resection.
Case Presentation: The patient was an 11-year-old male with right-sided abdominal pain.
Predictors of appropriate therapies delivered by the implantable cardioverter-defibrillator in patients with coronary artery disease during long-term period.
Int J Cardiovasc Imaging
September 2024
Academician of the Russian Academy of Sciences, Director, Department of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russian Federation, Kievskaya st., 111a, Tomsk, 634012, Russia.
This prospective study aimed to investigate the ability of cardiac autonomic nervous system (CANS) activity assessment to predict appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with coronary artery disease (CAD) during long-term follow-up period. We enrolled patients with CAD and ICD implantation indications that included both secondary and primary prevention of sudden cardiac death. Before ICD implantation CANS was assessed by using heart rate variability (HRV), myocardium scintigraphy with I-meta-iodobenzylguanidine (I-MIBG) and erythrocyte membranes β-adrenoreactivity (EMA).
View Article and Find Full Text PDFDiagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies.
J Alzheimers Dis
June 2024
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Background: Dementia with Lewy bodies (DLB) presents with various symptoms, posing challenges for early diagnosis challenging. Dopamine transporter (123I-FP-CIT) single-photon emission tomography (SPECT) and 123I-meta-iodobenzylguanidine (123I-MIBG) imaging are crucial diagnostic biomarkers. Hypothesis about body- and brain-first subtypes of DLB indicate that some DLB may show normal 123I-FP-CIT or 123I-MIBG results; but the characteristic expression of these two subtypes remains unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!