Moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. This study examined two newly identified proteins as potential vaccine antigens. Antisera raised to recombinant purified proteins Msp22 and Msp75 recognized corresponding native proteins in multiple strains of M. catarrhalis. Vaccine formulations individually administered subcutaneously and intranasally showed enhanced clearance of M. catarrhalis in a mouse pulmonary clearance model by both routes of administration. Msp22 and Msp75 are antigenically conserved proteins that induce potentially protective immune responses and should be examined further as vaccine antigens for M. catarrhalis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783942 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2009.09.062 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The characterization of carried in the general population.
Microb Genom
May 2022
Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
is a common cause of respiratory tract infection, particularly otitis media in children, whilst it is also associated with the onset of exacerbation in chronic obstructive pulmonary disease in adults. Despite the need for an efficacious vaccine against , no candidates have progressed to clinical trial. This study, therefore, aimed to characterize the diversity of isolated from the upper respiratory tract of healthy children and adults, to gain a better understanding of the epidemiology of and the distribution of genes associated with virulence factors, to aid vaccine efforts.
View Article and Find Full Text PDFCharacterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis.
Vaccine
November 2009
Department of Microbiology, University at Buffalo, The State University of New York, Buffalo, NY 14215, United States.
Moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. This study examined two newly identified proteins as potential vaccine antigens. Antisera raised to recombinant purified proteins Msp22 and Msp75 recognized corresponding native proteins in multiple strains of M.
View Article and Find Full Text PDFMining the Moraxella catarrhalis genome: identification of potential vaccine antigens expressed during human infection.
Infect Immun
April 2008
Department of Microbiology, University at Buffalo, State University of New York, Buffalo, New York, USA.
Moraxella catarrhalis is an important cause of respiratory infections in adults and otitis media in children. Developing an effective vaccine would reduce the morbidity, mortality, and costs associated with such infections. An unfinished genome sequence of a strain of M.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!