Six new neo-clerodane diterpenoid alkaloids, named scutehenanines A-D (1, 4, 5, 6), 6-O-acetylscutehenanine A (2), and 6-O-(2-carbonyl-3-methylbutanoyl)scutehenanine A (3), were isolated from the whole plant of Scutellaria barbata. Their structures were established on the basis of detailed physical data analyses. In vitro, the six new isolated compounds showed cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells) and gave IC50 values in the range 2.8-6.4 microM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np900362z | DOI Listing |
Publication Analysis
Top Keywords
neo-clerodane diterpenoid
8
diterpenoid alkaloids
8
scutellaria barbata
8
cytotoxic neo-clerodane
4
alkaloids scutellaria
4
barbata neo-clerodane
4
alkaloids named
4
named scutehenanines
4
scutehenanines a-d
4
a-d 6-o-acetylscutehenanine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!