Purpose: Establishing content validity for both new and existing patient-reported outcome (PRO) measures is central to a scientifically sound instrument development process. Methodological and logistical issues present a challenge in regard to determining the best practices for establishing content validity.
Methods: This paper provides an overview of the current state of knowledge regarding qualitative research to establish content validity based on the scientific methodological literature and authors' experience.
Results: Conceptual issues and frameworks for qualitative interview research, developing the interview discussion guide, reaching saturation, analysis of data, developing a theoretical model, item generation and cognitive debriefing are presented. Suggestions are offered for dealing with logistical issues regarding facilitator qualifications, ethics approval, sample recruitment, group logistics, taping and transcribing interviews, honoraria and documenting content validity.
Conclusions: It is hoped this paper will stimulate further discussion regarding best practices for establishing content validity so that, as the PRO field moves forward, qualitative research can be evaluated for quality and acceptability according to scientifically established principles.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11136-009-9540-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Automated, Quantitative Capillary Western Blots to Analyze Host Cell Proteins in COVID-19 Vaccine Produced in Vero Cell Line.
Vaccines (Basel)
December 2024
Analytical Research & Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Background/objectives: Host cell protein (HCP) content is a major attribute for biological and vaccine products that must be extensively characterized prior to product licensure. Enzyme Linked Immunosorbent Assay (ELISA) and Mass Spectrometry (MS) are conventional methods for quantitative host cell protein analysis in biologic and vaccine products. Both techniques are usually very tedious, labor-intensive, and challenging to transfer to other laboratories.
View Article and Find Full Text PDFCalibration and Performance Evaluation of Cost-Effective Capacitive Moisture Sensor in Slope Model Experiments.
Sensors (Basel)
December 2024
Graduate School of Information Science and Electrical Engineering, Kyushu University, Fukuoka 819-0395, Japan.
Understanding the factors that contribute to slope failures, such as soil saturation, is essential for mitigating rainfall-induced landslides. Cost-effective capacitive soil moisture sensors have the potential to be widely implemented across multiple sites for landslide early warning systems. However, these sensors need to be calibrated for specific applications to ensure high accuracy in readings.
View Article and Find Full Text PDFStyle Transfer of Chinese Wuhu Iron Paintings Using Hierarchical Visual Transformer.
Sensors (Basel)
December 2024
College of Computer Science and Engineering, Chongqing University of Technology, Chongqing 400054, China.
Within the domain of traditional art, Chinese Wuhu Iron Painting distinguishes itself through its distinctive craftsmanship, aesthetic expressiveness, and choice of materials, presenting a formidable challenge in the arena of stylistic transformation. This paper introduces an innovative Hierarchical Visual Transformer (HVT) framework aimed at achieving effectiveness and precision in the style transfer of Wuhu Iron Paintings. The study begins with an in-depth analysis of the artistic style of Wuhu Iron Paintings, extracting key stylistic elements that meet technical requirements for style conversion.
View Article and Find Full Text PDFQuantification of Amlodipine Maleate Content in Amorphous Solid Dispersions Produced by Fluidized Bed Granulation Using Process Analytical Technology Tools.
Pharmaceutics
December 2024
Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia.
Active pharmaceutical ingredient (API) content is a critical quality attribute (CQA) of amorphous solid dispersions (ASDs) prepared by spraying a solution of APIs and polymers onto the excipients in fluid bed granulator. This study presents four methods for quantifying API content during ASD preparation. Raman and three near-infrared (NIR) process analysers were utilized to develop methods for API quantification.
View Article and Find Full Text PDFComprehensive Physio-Biochemical Evaluation Reveals Promising Genotypes and Mechanisms for Cadmium Tolerance in Tibetan Hull-Less Barley.
Plants (Basel)
December 2024
Department of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
Cadmium (Cd) toxicity in agricultural soil is increasing globally and significantly impacts crop production and food safety. Tibetan hull-less barley ( L. var.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!