We sought to partition the genetic and environmental influences on lipoprotein subclasses and identify genomic regions that may harbor genetic variants that influence serum lipoprotein levels in a sample of Gullah-speaking African-Americans. We genotyped 5,974 SNPs in 979 subjects from 418 pedigrees and used the variance component approach to compute heritability estimates, genetic and environmental correlations, and linkage analyses for selected lipoprotein subclasses. The highest heritability estimate was observed for large VLDL particle concentration (0.56 +/- 0.14). Mean LDL particle size and small LDL particle concentration (-0.94) had the strongest genetic correlation estimate. The highest logarithm of odds (LOD) score detected (3.0) was on chromosome 6p24 for small LDL particle concentration. The strongest signal, obtained with the reduced sample of diabetic individuals only, was observed on chromosome 20p13 for small LDL particle concentration. The highest bivariate linkage signal (LOD 2.4) was observed on chromosome 6p24 for mean LDL particle size and small LDL particle concentration. Our results suggest a significant genetic contribution to multiple lipoprotein subclasses studied in this sample and that novel loci on chromosomes 6, 10, 16, and 20 may harbor genes contributing to small, atherogenic LDL particle concentration and large, triglyceride-rich VLDL particle concentration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817588 | PMC |
| http://dx.doi.org/10.1194/jlr.M001842 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of dissipation pathways for pharmaceuticals in soils - a modelling approach.
Environ Sci Process Impacts
January 2025
Eberhard Karls University of Tübingen, Department of Geosciences, Schnarrenbergstraße 94-96, 72076 Tübingen, Germany.
Concentrations of pollutants like pharmaceuticals in soils typically decrease over time, though it often remains unclear whether this dissipation is caused by the transformation of the pollutant or a decreasing extractability. We developed a mathematical model that (1) explores the plausibility of different dissipation pathways, and (2) allows the quantification of concentration differences between aqueous soil extracts and soil solution. The model considers soil particles as uniform spheres, kinetic sorption towards an equilibrium (Freundlich model), and two dissipation pathways, irreversible transformation and mineralization (following 1 order kinetics) as well as the formation of non-extractable residues intraparticle diffusion.
View Article and Find Full Text PDFSpatiotemporal Mapping of Ultrafine Particle Fluxes in an Office HVAC System with a Diffusion Charger Sensor Array.
ACS EST Air
January 2025
Lyles School of Civil & Construction Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Commercial HVAC systems intended to mitigate indoor air pollution are operated based on standards that exclude aerosols with smaller diameters, such as ultrafine particles (UFPs, D ≤ 100 nm), which dominate a large proportion of indoor and outdoor number-based particle size distributions. UFPs generated from occupant activities or infiltrating from the outdoors can be recirculated and accumulate indoors when they are not successfully filtered by an air handling unit. Monitoring UFPs in real occupied environments is vital to understanding these source and mitigation dynamics, but capturing their rapid transience across multiple locations can be challenging due to high-cost instrumentation.
View Article and Find Full Text PDFDetecting two circulating antigens - CCA and CAA - in urine and serum to improve diagnosis of human schistosomiasis.
Front Parasitol
October 2024
Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
Background: Schistosomiasis is caused by infection with parasitic worms and affects more than 250 million people globally. The detection of schistosome derived circulating cathodic and anodic antigens (CCA and CAA) has proven highly valuable for detecting active infections, causing both intestinal and urinary schistosomiasis.
Aim: The combined detection of CCA and CAA was explored to improve accuracy in detecting infections.
Antioxidant, anti-collagenase, and antibacterial activities of us silver nanoparticles.
Narra J
December 2024
Department of Biology, Faculty of Science and Technology, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia.
is an alga with high fucoxanthin, phlorotannin, fucoidan, sterol, and astaxanthin. The silver nanoparticles of (AgNPs-Fv) are expected to have high antioxidant, anti-collagenase, and antibacterial activities. The aim of this study was to characterize the distribution and size of AgNPs-Fv and determine their antioxidant, anti-collagenase, and antibacterial activities.
View Article and Find Full Text PDFImproved Mechanistic Modeling on Reproducing Particle-Bound Mercury in the Marine Atmosphere.
Environ Sci Technol
January 2025
Key Laboratory of Geographic Information Science (Ministry of Education), School of Geographic Sciences, East China Normal University, Shanghai 200241, China.
Mercury (Hg) is a neurotoxic pollutant that is ubiquitous on the planet and receives global concern because of its adverse health effects. Particle-bound Hg formation in the atmosphere stems mainly from the adsorption of reactive gaseous Hg on aerosol particles, particularly sea salt aerosol. However, the observed comparable abundance of Hg over Hg in the marine atmosphere has not been reproduced by traditional statistics-based schemes, which were constructed by continental observations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!