In this retrospective autopsy study fire-related deaths whose autopsies were carried out in the Council of Forensic Medicine in Istanbul, Turkey were analyzed in order to evaluate the relationship between the mode of the death and the laboratory and autopsy findings. There were 320 fire-related fatalities constituting the 2.07% of all autopsy cases of that period. Of the 320 cases 228 (71.3%) were males and 91 (28.4%) were females, average age in age-determined group was 36.6 (SD: 21.98) ranging from 8 months to 98 years. Carbon monoxide intoxication played role in death of 104 cases (32.5%) either directly or together with other factors such as burning and lack of oxygen. In 32 cases (10.0%) burning was the only cause of death and in 90 cases (28.1%) burning and related complications during treatment period caused death. In 35 cases (10.9%) traumatic factors other than those related to fire were responsible for death. There were 31 cases of homicide (9.7%) and 20 cases of suicide (6.3%). Accidents constituted the majority of the cases in our autopsy population with a frequency of 51.9%. The relationship between the presence of soot in trachea or esophagus and the mode of death and that of CO-Hb and the mode of death was statistically significant. The internal findings and laboratory data of the study population were discussed particularly on the basis of the decision of vitality in burned cases.
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http://dx.doi.org/10.1016/j.jflm.2009.05.005 | DOI Listing |
Indian J Clin Biochem
January 2025
Department of Biochemistry, College of Medicine and J.N.M Hospital, WBUHS, Kalyani, West Bengal 741235 India.
Radiation therapy uses ionizing radiation (IR) to kill cancer cells. However, during radiotherapy normal cells are also damaged and killed by the generation of reactive oxygen species. Polyphenolic compounds are known to mitigate the damaging effects of radiation.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Hematology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of B-cell non-Hodgkin's lymphoma (NHL), up to 30%-40% of patients will relapse and 10%-15% of patients have primary refractory disease, so exploring new treatment options is necessary. Ferroptosis is a non-apoptotic cell death mode discovered in recent years. Its occurrence pathway plays an essential impact on the therapeutic effect of tumors.
View Article and Find Full Text PDFFront Cell Dev Biol
January 2025
Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Muscle repair and regeneration are complex processes. In Duchenne muscular dystrophy (DMD), these processes are disrupted by the loss of functional dystrophin, a key part of the transmembrane dystrophin-associated glycoprotein complex that stabilizes myofibers, indirectly leading to progressive muscle wasting, subsequent loss of ambulation, respiratory and cardiac insufficiency, and premature death. As part of the DMD pathology, histone deacetylase (HDAC) activity is constitutively increased, leading to epigenetic changes and inhibition of muscle regeneration factors, chronic inflammation, fibrosis, and adipogenesis.
View Article and Find Full Text PDFBrain Res Bull
January 2025
Department of Radiology, Chongqing University Cancer Hospital. Electronic address:
Background: Cancer pain is a common symptom in patients with malignant tumors and associated with poor prognosis and a high risk of death. Structural connectivity (SC) and functional connectivity (FC) couplings have not yet been explored in lung cancer patients with bone metastasis pain.
Methods: In total, 51 patients with lung cancer without bone metastasis pain (BMP-), 52 patients with lung cancer with bone metastasis pain (BMP+), and 28 healthy controls (HC) were prospectively enrolled in our study.
J Adv Res
January 2025
Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address:
Introduction: Pyroptosis represents a mode of programmed necrotic cell death (PCD), mediated by members of gasdermin family (GSDMs), such as GSDME. It is emerging as a promising approach for combating cancer. Notably, GSDME is the key modulator for the switch between apoptosis and pyroptosis in cells.
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