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Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis.
J Neurol
December 2024
Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Background And Objectives: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).
Methods: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.
Chimeric antigen receptor-T-cell therapies going viral: latent and incidental viral infections.
Curr Opin Infect Dis
December 2024
Vaccine and Infectious Disease Division.
Article Synopsis
- Infections, especially from viruses, are a major cause of problems after CAR-T-cell therapy, which is a type of cancer treatment.
- Herpes viruses are common right after treatment, and while some are rare now due to medicine, the cytomegalovirus (CMV) can still be a serious issue for some patients.
- To help protect patients from these infections, better vaccination timing and types need to be researched, as vaccines may not work as well after the treatment.
Human Herpesvirus 6-A Rare Aetiologic Agent for CNS Infections in Immunocompetent Individuals or an Underestimation?
J Clin Med
August 2024
Faculty of General Medicine, Department of Infectious Diseases, "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, 010458 Bucharest, Romania.
Article Synopsis
- Human herpesvirus 6 (HHV-6) is widely prevalent, with over 80-90% of people showing infection, and it uniquely integrates into human DNA, leading to different types of infections.
- A study analyzed patients with central nervous system (CNS) infections in Romania and found 5% had HHV-6 in their cerebrospinal fluid (CSF), with 2-4% showing active infections.
- No significant associations were found between HHV-6 positivity in CSF and factors like age, sex, or health conditions, indicating that identifiable risk factors for HHV-6 CNS infections may be limited.*
Cytokine Dynamics and Herpesvirus Interactions in Pediatric Liver and Kidney Transplant Recipients: The Distinct Behavior of HCMV, HHV6, HHV7 and EBV.
Viruses
July 2024
Clinical Pathology Department, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico.
Article Synopsis
- * In a study measuring cytokine levels in 158 pediatric kidney and liver transplant patients, higher levels of IL-4, IL-8, and IL-10 were found to be associated with graft rejection, especially in cases with certain herpesviruses present.
- * The research stresses the need for closer monitoring of not just EBV and HCMV, but also HHV6 and HHV7 to improve risk assessment and treatment strategies for pediatric transplant patients.
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