AI Article Synopsis
- * Understanding how these complexes interact with DNA and the cellular processes involved in getting DNA into cells can help improve their design for gene therapy.
- * The text highlights recent advances in the mechanisms of how lipoplexes work and reviews common techniques used to study gene delivery methods.
Article Abstract
Cationic lipid/DNA complexes (lipoplexes) represent an attractive alternative to viral vectors for cell transfection in vitro and in vivo but still suffer from relatively low efficiency. Comprehension of the interactions between vectors and DNA as well as cellular pathways and mechanisms in DNA entry into cells and ultimately nuclei will lead to the design of better adapted non-viral vectors for gene therapy applications. Here, some recent developments in the field on the pathways and mechanisms involved in lipoplex-mediated transfection are discussed. The techniques that are widely used to study the mechanism of gene delivery are also discussed.
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| http://dx.doi.org/10.1517/17425240903287153 | DOI Listing |
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