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Consolidation of the Anteromedial Aspect of the Tibia is Inferior to The Other Areas in the Reconstruction of Critical-Sized Bone Defect of the Tibial Shaft using the Induced Membrane Technique: An Analysis of 111 Serial Computed Tomography of 37 patients.
J Orthop Trauma
October 2024
Department of Orthopaedic Surgery, Guro Hospital, Korea University Medical Center, Seoul, Republic of Korea.
Objectives: To compare the consolidation quality between the anteromedial aspect of regenerated bone (AMRB) and other areas of regenerated bone (TORB) following the induced membrane technique (IMT) for managing critical-sized tibial shaft bone defects, and determine the factors affecting consolidation quality in the AMRB.
Methods: Design: Retrospective comparative study.
Setting: Academic Level I trauma center.
Background: In recent efforts to improve early identification, staging, and prediction of risk of persons at risk for vascular contributions to cognitive impairment and dementia (VCID) in relation with small vessel disease (SVD), the MarkVCID consortium has worked to identify and validate fluid- and imaging-based biomarkers for SVD associated with VCID. Free water (FW) measured derived from diffusion tensor imaging and one of the selected neuroimaging biomarker "kits", has been demonstrated to have excellent instrumental validity and to be a sensitive biomarker of cognitive performances. We sought to further examine FW clinical relevance by investigating whether FW predicts cognitive worsening over time.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Background: To aid development of prevention strategies, we investigated whether a composite measure of late-midlife lifestyle health was associated with (1) change in brain tau burden, vascular burden and neurodegeneration and (2) cognitive trajectories when accounting for these brain changes.
Method: We included 324 individuals from the Wisconsin Registry for Alzheimer's Prevention. Late-midlife lifestyle was assessed using the Lifestyle for Brain Health (LIBRA) score, encompassing 12 risk-and protective factors for cognitive decline and dementia.
Background: Glymphatic system dysfunction as characterized by increased MRI-visible Perivascular Spaces (PVS) is speculated to play a role in the acceleration of amyloid accumulation in Alzheimer's Disease (AD). However, while PVS is also prevalent amongst Vascular Dementia (VD), the pathological distinctions between regional PVS in AD- and VD-driven cohorts remain largely unknown. Through a mixed dementia cohort, we examined these pathology-driven localization patterns via automated PVS segmentations from T2-weighted MRI.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Background: Olfactory deficits are predictive of cognitive decline and dementia. Previous studies have linked brain magnetic resonance imaging markers of neurodegeneration to olfactory deficits in aging; however, these studies analyzed cross-sectional data for markers, olfaction, or both. Furthermore, potential cerebrovascular contributions to understanding why olfactory deficits predict dementia remain unexplored.
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