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Mapping rare protein-coding variants on multi-organ imaging traits.
medRxiv
November 2024
Graduate Group in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Human organ structure and function are important endophenotypes for clinical outcomes. Genome-wide association studies (GWAS) have identified numerous common variants associated with phenotypes derived from magnetic resonance imaging (MRI) of the brain and body. However, the role of rare protein-coding variations affecting organ size and function is largely unknown.
View Article and Find Full Text PDFB cells enhance EphA2 chimeric antigen receptor T cells cytotoxicity against glioblastoma via improving persistence.
Hum Immunol
November 2024
Beijing Key Laboratory for Therapeutic Cancer Vaccines, Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Electronic address:
Chimeric antigen receptor (CAR) T cell therapy is a powerful adoptive immunotherapy against blood cancers, but the therapeutic effect was not efficient enough on solid tumors. B cells have been reported to play a critical role in regulating memory T differentiation and cytotoxic T development. However, as of yet the influence of such B cells on CAR T cells has not been discussed.
View Article and Find Full Text PDFContributions of each of the BAFF receptors to the lymphocyte profiles in C57BL/6 mice.
Immunology
December 2024
New York State Psychiatric Institute, New York, New York, USA.
BAFF, a vital B cell survival and differentiation factor, has three receptors: B-cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI) and BR3. Although B cells are greatly reduced in B6.Baff (which harbour no BAFF) and B6.
View Article and Find Full Text PDFGenome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media.
Sci Rep
August 2024
Biocenter Oulu and the Research Unit of Population Health, University of Oulu, Oulu, Finland.
To evaluate the genetics of chronic nonsuppurative otitis media (OM). We performed a genome-wide association study of 429,599 individuals included in the FinnGen study using three different case definitions: combined chronic nonsuppurative OM (7034 cases) (included serous and mucous chronic OM), mucous chronic OM (5953 cases), and secretory chronic OM (1689 cases). Individuals without otitis media were used as controls (417,745 controls).
View Article and Find Full Text PDFIntermediate uveitis in common variable immunodeficiency (CVID) associated with a heterozygous variant in the TNFRSF13B gene.
Retin Cases Brief Rep
July 2024
Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium.
Article Synopsis
- - A rare case of intermediate uveitis was reported in a 23-year-old male with common variable immunodeficiency (CVID) and a specific genetic variant (TNFRSF13B).
- - The patient experienced blurred vision and floaters in both eyes, with a previous ineffective treatment using corticosteroids, leading to the discovery of bilateral uveitis and retinal vasculitis.
- - After switching from mycophenolate mofetil to adalimumab, the patient achieved clinical remission, suggesting the importance of anti-TNF therapy in CVID-related eye conditions.
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