AI Article Synopsis
- Calcium D-glucarate was successfully converted to D-glucaro-1,4:6,3-dilactone using azeotropic distillation with methyl isobutyl ketone for dehydration.
- The process was executed on different scales (32-g, 1-kg, and 22-kg) demonstrating versatility in production.
- The final crystalline product achieved a purity of at least 99.5% as confirmed by GC and NMR, with an overall yield of up to 72%.
Article Abstract
Calcium D-glucarate was converted into D-glucaro-1,4:6,3-dilactone on 32-g, 1-kg, and 22-kg scale, using azeotropic distillation with methyl isobutyl ketone to drive the dehydration. The crystalline product was > or = 99.5% pure by GC and NMR, and overall yield was as high as 72%.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo9015985 | DOI Listing |
Publication Analysis
Top Keywords
convenient large-scale
4
large-scale synthesis
4
synthesis d-glucaro-1463-dilactone
4
d-glucaro-1463-dilactone calcium
4
calcium d-glucarate
4
d-glucarate converted
4
converted d-glucaro-1463-dilactone
4
d-glucaro-1463-dilactone 32-g
4
32-g 1-kg
4
1-kg 22-kg
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!