Ca(2+)-induced opening of the mitochondrial permeability transition pore (MPTP) is involved in induction of apoptotic and necrotic processes. We studied sensitivity of MPTP to calcium using the model of Ca(2+)-induced, cyclosporine A-sensitive mitochondrial swelling. Presented data indicate that the extent of mitochondrial swelling (dA520/4 min) induced by addition of 25 microM Ca2+ is seven-fold higher in liver than in heart mitochondria (0.564 +/- 0.08/0.077 +/- 0.01). The extent of swelling induced by 100 microM Ca2+ was in liver tree times higher than in heart mitochondria (0.508 +/- 0.05/ 0.173 +/- 0.02). Cyclosporine A sensitivity showed that opening of the MPTP is involved. We may thus conclude that especially at low Ca2+ concentration heart mitochondria are more resistant to damaging effect of Ca2+ than liver mitochondria. These finding thus support hypothesis that there exist tissue specific strategies of cell protection against induction of the apoptotic and necrotic processes.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Alpha-Synuclein Effects on Mitochondrial Quality Control in Parkinson's Disease.
Biomolecules
December 2024
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
The maintenance of healthy mitochondria is essential for neuronal survival and relies upon mitochondrial quality control pathways involved in mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial autophagy (mitophagy). Mitochondrial dysfunction is critically implicated in Parkinson's disease (PD), a brain disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Consequently, impaired mitochondrial quality control may play a key role in PD pathology.
View Article and Find Full Text PDFMitophagy in Doxorubicin-Induced Cardiotoxicity: Insights into Molecular Biology and Novel Therapeutic Strategies.
Biomolecules
December 2024
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Doxorubicin is a chemotherapeutic drug utilized for solid tumors and hematologic malignancies, but its clinical application is hampered by life-threatening cardiotoxicity, including cardiac dilation and heart failure. Mitophagy, a cargo-specific form of autophagy, is specifically used to eliminate damaged mitochondria in autophagosomes through hydrolytic degradation following fusion with lysosomes. Recent advances have unveiled a major role for defective mitophagy in the etiology of DOX-induced cardiotoxicity.
View Article and Find Full Text PDFMitochondrial Dysfunction in Cardiac Disease: The Fort Fell.
Biomolecules
November 2024
Department of Cardiology, Hygeia Hospital, 15123 Athens, Greece.
Myocardial cells and the extracellular matrix achieve their functions through the availability of energy. In fact, the mechanical and electrical properties of the heart are heavily dependent on the balance between energy production and consumption. The energy produced is utilized in various forms, including kinetic, dynamic, and thermal energy.
View Article and Find Full Text PDFThe effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I.
Genes Dis
March 2025
Department of Cardiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
Article Synopsis
- Aging increases the risk of cardiovascular diseases, particularly cardiac diastolic dysfunction (CDD), which can lead to heart failure with preserved ejection fraction (HFpEF) in older adults.
- Research indicates that green tea catechins, specifically epigallocatechin gallate (EGCG), may help improve cardiovascular issues related to aging in both animal models and humans, yet studies on its long-term effects on CDD are limited.
- In this study, older mice treated with EGCG showed a prevention of aging-related CDD and improvements in heart function, attributed to enhanced expression of cardiac troponin I (cTnI) and reduced mitochondrial damage through the inhibition of histone deacetylase 1 (HDAC1).
Understanding the Complexity of Hypertension with Sarcopenia by Scientometric Analysis.
J Multidiscip Healthc
December 2024
Department of General Practice, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, WuHan, Hubei, People's Republic of China.
Objective: The scientometric analysis was aim to focus on recent studies and clarify new research directions on hypertension with sarcopenia. We hope to provide comprehensive insights or actionable recommendations for clinicians or policymakers.
Methods: The Web of Science Core Collection database (WoSCC) from 2004 to 2023 for analysis was used.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!