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Chronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model.
Front Pharmacol
December 2024
Addiction Research Group, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Introduction: Prenatal nicotine exposure (PNE) from maternal smoking disrupts regulatory processes vital to fetal development. These changes result in long-term behavioral impairments, including mood and anxiety disorders, that manifest later in life. However, the relationship underlying PNE, and the underpinnings of mood and anxiety molecular and transcriptomic phenotypes remains elusive.
View Article and Find Full Text PDFUnderstanding the role of environment in associative learning of nicotine-induced place preference conditioning in zebrafish.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Department of Physiology and Institute of Physiology and Biophysics, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina. Electronic address:
Environmental enrichment (EE) is a well-known strategy in animal behavior to improve the welfare and health of animals in captivity. EE provides animals with stimulating and engaging environments that promote natural behaviors, cognitive stimulation and stress reduction. EE turns out to be an important strategy to increase the validity and reproducibility of behavioral data.
View Article and Find Full Text PDFMetabolomic Analysis of Nicotine-Induced Metabolic Disruptions and Their Amelioration by Resveratrol.
J Biochem Mol Toxicol
January 2025
Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
This study investigates the metabolic disruptions caused by nicotine (NIC) exposure, with a particular focus on amino acid and lipid metabolism, and evaluates resveratrol (RSV) as a potential protective agent. Mice were divided into four groups: control (CON), NIC-exposed, NIC + RSV-treated, and RSV-only. NIC exposure resulted in significant weight loss, elevated glucose levels, altered lipid profiles, and organ damage, particularly in the liver and kidneys.
View Article and Find Full Text PDFThe Effects of Electronic Cigarettes on Oral Microbiome and Metabolome in 3D Tissue-Engineered Models.
Int Dent J
December 2024
Department of Restorative Dentistry, Hamdan Bin Mohammed College of Dental Medicine (HBMCDM), Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai Health, Dubai, United Arab Emirates; Department of Restorative Dentistry, School of Clinical Dentistry, University of Sheffield, Sheffield, UK. Electronic address:
Background And Aim: Recent studies have shown that electronic cigarettes (ECs) use disrupts the oral microbiome composition and diversity, impairing the metabolic pathways of the mucosal cells. However, to date, no reports have evaluated the role of EC exposure in the context of oral metabolome. Hence, the aim of this study was to investigate the role of EC aerosol exposure in the dysregulation of the oral microbiome and metabolome profile using in vitro 3D organotypic models of human oral mucosa.
View Article and Find Full Text PDFE-Cigarette effects on oral health: A molecular perspective.
Food Chem Toxicol
December 2024
Department of Otolaryngology-Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; TSET Health Promotion Research Center, Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. Electronic address:
Electronic cigarettes (e-cigarettes) have emerged as a potential alternative to traditional smoking and may aid in tobacco harm reduction and smoking cessation. E-cigarette use has notably increased, especially among young non-tobacco users, raising concerns due to the unknown long-term health effects. The oral cavity is the first and one of the most crucial anatomical sites for the deposition of e-cigarette aerosols.
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