We report the synthesis of telechelic poly(norbornene) and poly(cyclooctene) homopolymers by ring-opening metathesis polymerization (ROMP) and their subsequent functionalization and block copolymer formation based on noncovalent interactions. Whereas all the poly(norbornene)s contain either a metal complex or a hydrogen-bonding moiety along the polymer side-chains, together with a single hydrogen-bonding-based molecular recognition moiety at one terminal end of the polymer chain. These homopolymers allow for the formation of side-chain-functionalized AB and ABA block copolymers through self-assembly. The orthogonal natures of all side- and main-chain self-assembly events were demonstrated by (1)H NMR spectroscopy and isothermal titration calorimetry. The resulting fully functionalized block copolymers are the first copolymers combining both side- and main-chain self-assembly, thereby providing a high degree of control over copolymer functionalization and architecture and bringing synthetic materials one step closer to the dynamic self-assembly structures found in nature.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.200801647 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Organometallic-Polypeptide Block Copolymers: Synthesis and Crystallization-Driven Self-Assembly in Aqueous Solutions to Rod-like and Plate-like Micelles with Polypeptide Coronas.
Chemistry
January 2025
University of Toronto, Chemistry, 80 St George Street, M5S 3H6, Toronto, CANADA.
The synthesis of polyferrocenyldimethylsilane-b-poly(L-glutamic acid) block copolymers was systematically explored. Rod-like and plate-like micelles were prepared from self-assembly of the block copolymers in aqueous solution with two different approaches. In a dissolution-dialysis approach, micelles were prepared by dissolving a block copolymer sample in excess aqueous base followed by the dialysis of the solution against water.
View Article and Find Full Text PDFSelf-assembly of malto-oligosaccharide-block-solanesol in aqueous solutions: Investigating morphology and sugar-based physiological compatibility.
Carbohydr Polym
March 2025
Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan. Electronic address:
Starch-derived hydrophilic malto-oligosaccharides (Glc, where n = 1-7) conjugated to hydrophobic solanesol through click chemistry, i.e., Glc-b-Sol copolymers, have demonstrated significant promise in developing fully natural block co-oligomers for solid-state nanopatterning applications.
View Article and Find Full Text PDFDextran-block-poly(benzyl glutamate) block copolymers via aqueous polymerization-induced self-assembly.
Carbohydr Polym
March 2025
Department of Chemistry, Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA; Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address:
Combining polysaccharides with polypeptides enables growth of diverse nanostructures with minimal toxicity, low immune response, and potential biodegradability. However, examples of nanostructures combining polysaccharides with polypeptides are limited due to synthetic difficulties and related issues of solubility, purification, and characterization, with previous reports of polysaccharide-block-polypeptide block copolymers requiring methods such as polymer-polymer coupling and post-polymerization modifications paired with difficult purification steps. Here, we synthesized dextran-block-poly(benzyl glutamate) block copolymers in water via polymerization-induced self-assembly (PISA) to form nanostructures in situ, studying their morphologies using experimental methods and molecular modeling.
View Article and Find Full Text PDFFully biosourced amphiphilic block copolymer from tamarind seed xyloglucan and solanesol: synthesis, aqueous self-assembly, and drug encapsulation.
Carbohydr Polym
March 2025
Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan. Electronic address:
This study aims to explore the development of natural bio-based amphiphilic block copolymers for drug delivery applications. We investigated block copolymers derived from tamarind seed xyloglucan and solanesol, focusing on their synthesis, structural analysis, aqueous self-assembly, and drug encapsulation. Specifically, xyloglucan hydrolysate segments with number-average degrees of polymerization (DPs) of between 8 and 44 (XOS, XMS, XMS, XMS, and XMS) were used as the hydrophilic blocks, whereas plant-sourced solanesol was selected as the hydrophobic segment.
View Article and Find Full Text PDFInvestigating the interactions between a poloxamer and TEMPO-oxidised cellulose nanocrystals.
Carbohydr Polym
March 2025
Bristol Composites Institute, School of Civil, Aerospace, and Design Engineering, University of Bristol, University Walk, Bristol BS8 1TR, UK. Electronic address:
Cellulose nanocrystals (CNCs) have emerged as promising, sustainable materials, with applications in sensors, coatings, pharmaceuticals, and composites. Their modification with block copolymers such as PEO-PPO-PEO triblock copolymers of the Pluronic family has been attempted many times in the literature, with claims that such modification would happen by an anchor(PEO)-buoy(PPO)-anchor(PEO) mechanism. However, there is much disagreement in the literature on this.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!