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Analysis of the risk of oncological adverse events associated with infliximab in combination with azathioprine compared to monotherapy: insights from the FAERS database.
Front Pharmacol
January 2025
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.
Objective: This study aimed to evaluate the risk of tumor formation with infliximab or azathioprine monotherapy versus their combination, using the FDA Adverse Event Reporting System (FAERS) database.
Methods: Data were extracted from the FAERS database for patients treated with infliximab, azathioprine, and combination therapy from Q1 2004 to Q2 2024. Signal mining employed methods such as Reported Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Multiple Gamma-Poisson Scaling Assessment (MGPSA) and Bayesian Confidence Interval Progressive Neural Network (BCPNN).
Optimizing multi label student performance prediction with GNN-TINet: A contextual multidimensional deep learning framework.
PLoS One
January 2025
Department of Information Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
As education increasingly relies on data-driven methodologies, accurately predicting student performance is essential for implementing timely and effective interventions. The California Student Performance Dataset offers a distinctive basis for analyzing complex elements that affect educational results, such as student demographics, academic behaviours, and emotional health. This study presents the GNN-Transformer-InceptionNet (GNN-TINet) model to overcome the constraints of prior models that fail to effectively capture intricate interactions in multi-label contexts, where students may display numerous performance categories concurrently.
View Article and Find Full Text PDFHepatotoxicity of statins: a real-world study based on the US Food and Drug Administration Adverse Event Reporting System database.
Front Pharmacol
January 2025
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Statins, as an important class of lipid-lowering drugs, play a key role in the prevention and treatment of cardiovascular diseases. However, with their widespread use in clinical practice, some adverse events have gradually emerged. In particular, the hepatotoxicity associated with statins use has become one of the clinical concerns that require sufficient attention.
View Article and Find Full Text PDFA study on the exploration of mild cognitive impairment in Parkinson's disease based on decision-making cognitive computing.
Front Neurosci
January 2025
Department of Neurology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Mild cognitive impairment in Parkinson's disease (PD-MCI) as an independent risk factor for dementia in Parkinson's disease has prognostic value in predicting dementia in PD patients. It was found that the calculation of cognitive function decision-making could better evaluate the cognitive function of PD-MCI. Therefore, this study explored deficits in decision-making cognitive function in PD-MCI population, and mined novel digital biomarkers for recognizing early cognitive decline in PD-MCI through an independently designed maze decision-making digital assessment paradigm.
View Article and Find Full Text PDFThe influence of contemporary and emerging factors on blood lead concentrations among young males in conflict with the law: a case study from a middle-income country.
Front Epidemiol
January 2025
Department of Environmental Health, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.
Introduction: Scientific evidence shows that contemporary and emerging factors contribute to high blood lead concentrations in different populations. The study aimed to determine blood lead concentrations and risk factors associated with high blood lead concentrations among young males in conflict with the law.
Methods: A cross-sectional analytical study was conducted among 192 conveniently selected participants from two youth secure (correctional) facilities in Gauteng Province, South Africa.
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