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| http://dx.doi.org/10.1021/cr900223a | DOI Listing |
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Expression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa.
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Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Center of Functional Genomics, Berlin, Germany.
The zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone. The primary role of aldosterone is the maintenance of volume and electrolyte homeostasis. Aldosterone synthesis is primarily regulated via tightly controlled oscillations in intracellular calcium levels in response to stimulation.
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Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: Atypical ductal hyperplasia (ADH) is a benign proliferative breast lesion. Surgical excision of ADH is often recommended to rule out underlying malignant disease.
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Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Rapid structural analysis of purified proteins and their complexes has become increasingly common thanks to key methodological advances in cryo-electron microscopy (cryo-EM) and associated data processing software packages. In contrast, analogous structural analysis in cells via cryo-electron tomography (cryo-ET) remains challenging due to critical technical bottlenecks, including low-throughput sample preparation and imaging, and laborious data processing methods. Here, we describe a rapid in situ cryo-ET sample preparation and data analysis workflow that results in the routine determination of sub-nm resolution ribosomal structures.
View Article and Find Full Text PDFCan a single coastal tide gauge help predict internal solitary wave activity offshore.
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Laboratoire d'Océanographie Physique et Spatiale (LOPS), IUEM, CNRS, Ifremer, IRD, University of Brest, 29280, Plouzané, France.
Internal solitary waves (ISWs) propagate in stratified waters, enhancing diapycnal mixing, sediment and mass transport on shelves. They have typical wavelengths of hundreds of meters and tens of minutes periods, requiring high resolution and high frequency measurements for their sampling. But such in-situ measurements are scarce and ISWs remain largely unpredictable.
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The Department of Medical Imaging, Guangzhou Key Laboratory of Molecular Functional Imaging and Artificial Intelligence for Major Brain Diseases, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Jinan University, Guangzhou 518037 China. Electronic address:
Microwave dynamic therapy (MWDT) destroy tumor cells using reactive oxygen species (ROS), but its effectiveness is limited by low ROS production and intracellular oxygen (O) availability. This study presents a novel strategy using manganese (II) ion (Mn) doped iron (Fe)-based metal-organic framework (Fe MOF) nanoparticles (NPs) to enhance both O generation and ROS production for improved MWDT. Incorporating Mn into Fe MOF narrows the bandgap from 0.
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