Gold salts are used mainly in the therapy of rheumatoid diseases. Thanks to their immunoregulative and antiinflammatory properties they may be used in treatment of chronic bronchial asthma. In order to study the efficacy of gold salts in such therapy the authors studied the effect of Solganal B (Schering) in 8 patients with chronic steroid dependent bronchial asthma. In 6 patients a clinical improvement was observed enabling to lower the steroid dose. Basing on this pilot study we believe that gold salts have an beneficial effect on the course of chronic bronchial asthma.
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Chem Sci
January 2025
Environmental Science and Engineering (EnSE) Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Kingdom of Saudi Arabia
Water microdroplets containing 100 μM HAuCl have been shown to reduce gold ions into gold nanoparticles spontaneously. It has been suggested that this chemical transformation takes place exclusively at the air-water interface of microdroplets, albeit without mechanistic insights. We compared the fate of several metallic salts in water, methanol, ethanol, and acetonitrile in the bulk phase and microdroplet geometry (sprays).
View Article and Find Full Text PDFLangmuir
November 2024
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
For millennia, humankind has discovered great benefits in alloying materials. Over the past 100 years, a renaissance in nanoscience has cemented the importance of nanoparticles in a variety of fields ranging from energy storage and conversion to cell biology. While many synthetic strategies exist for nanoparticle and alloy nanoparticle formation, new methods are necessary to create nanoparticles under unprecedented conditions.
View Article and Find Full Text PDFJ Org Chem
November 2024
Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, Via Vetoio, 67100 Coppito, AQ, Italy.
The distinctive features of gold self-relay catalysts were alternatively utilized in the intriguing cascade condensation of 2-aminobenzaldehydes with alcohols and amines. Using NaAuCl·2HO as a catalyst, a range of 13-alkyloxy-7,11-dihydro-6,13-6,12-[1,2]benzenoquinazolino[3,4-]quinazoline derivatives was produced in good to high yields through AB condensation of various 2-aminobenzaldehydes with alcohols. By carefully choosing the reaction conditions, gold catalysis also proved effective for AB condensation with primary aryl- and benzylamines, facilitating the synthesis of challenging McGeachin bisaminals, including a chiral nonracemic derivative of 2-()-methylbenzylamine.
View Article and Find Full Text PDFSci Rep
October 2024
Institute of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University of Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
Histological analysis with 2,3,5-triphenyltetrazolium chloride (TTC) staining is the most frequently used tool to detect myocardial ischemia/reperfusion injury. However, its practicality is often challenged by poor image quality in gross histology, leading to an equivocal infarct-boundary delineation and potentially compromised measurement accuracy. Here, we introduce several crucial refinements in staining protocol and sample processing, which enable TTC images to be analyzed with light microscopy.
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