An optical frequency distribution system has been developed that continuously delivers a stable optical frequency of 268 THz (corresponding to a wavelength of 1118 nm) to different experiments in our institute. For that purpose, a continuous wave (cw) fiber laser has been stabilized onto a frequency comb and distributed across the building by the use of a fiber network. While the light propagates through the fiber, acoustic and thermal effects counteract against the stability and accuracy of the system. However, by employing proper stabilization methods a stability of 2 x 10(-13) tau(-1/2) is achieved, limited by the available radio frequency (RF) reference. Furthermore, the issue of counter-dependant results of the Allan deviation was examined during the data evaluation.
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http://dx.doi.org/10.1364/OE.17.016849 | DOI Listing |
West Afr J Med
September 2024
Department of Ophthalmology, University of Calabar, Calabar, Cross River State, Nigeria.
Background: Strabismus is a potential cause of ocular morbidity.
Objective: The aim of this study was to determine the frequency, types of manifest strabismus and co-morbidities among patients attending a referral paediatric ophthalmology and strabismus clinic in Calabar, Nigeria.
Methods: A retrospective review of case-notes of patients attending the paediatric ophthalmology and strabismus clinic from January 1, 2017 to December 31, 2019 was done.
Ann Med
December 2025
Department of Neurology, Peking University First Hospital, China.
Objective: Whereas a few studies have evaluated vestibular involvement in Fabry disease (FD), the relationship between vestibular/oculomotor abnormalities and disease-specific biomarkers remain unclear. Therefore, we seek to evaluate these quantitatively and analyze their relationship with disease phenotype and biomarkers in FD.
Methods: This cohort study enrolled 37 Chinese FD patients registered in our center.
Br J Hosp Med (Lond)
January 2025
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
The relationship between retinal fundus hemorrhage and the severity of coronary artery lesions remains unclear. This study aimed to explore the incidence of fundus hemorrhage in patients at high risk of coronary heart disease (CHD) and to examine its correlation with the SYNTAX score, a tool used to assess the complexity of coronary artery disease. This retrospective study consecutively enrolled patients undergoing coronary angiography (CAG) at Beijing Anzhen Hospital Hospital from June 2019 to January 2020.
View Article and Find Full Text PDFJ Integr Neurosci
January 2025
Neuroscience Department, University of Connecticut Health, School of Medicine, Institute for Systems Genomics, Farmington, CT 06030, USA.
Background: In neuroscience, Ca imaging is a prevalent technique used to infer neuronal electrical activity, often relying on optical signals recorded at low sampling rates (3 to 30 Hz) across multiple neurons simultaneously. This study investigated whether increasing the sampling rate preserves critical information that may be missed at slower acquisition speeds.
Methods: Primary neuronal cultures were prepared from the cortex of newborn pups.
Viruses
December 2024
Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA.
Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. Using an AI-based analytical platform on meta cohorts, we profiled expression patterns of viral transcripts and HPV viral genome integration, and classified the tumor microenvironment (TME). Unsupervised clustering analysis revealed five distinct and novel TME subtypes across patients (immune-enriched, highly immune and B-cell enriched, fibrotic, immune-desert, and immune-enriched luminal).
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