AI Article Synopsis
- MDMA, known as "ecstasy," enhances sensory stimulation but its effects on sensory input were previously unexplored in research.
- Acute MDMA administration increases locomotor activity while reducing sensory input in rats, indicating a complex interaction with sensory processing.
- Chronic MDMA use leads to behavioral sensitization and decreases baseline sensory evoked potentials, but reintroducing MDMA can enhance these potentials in the prefrontal cortex.
Article Abstract
Ingestion of 3, 4-methylenedioxymethamphetamine (MDMA) leads to heightened response to sensory stimulation; thus, MDMA is referred to as "ecstasy" because it produces pleasurable enhancement of such sensation. There have been no electrophysiological studies that report the consequences of MDMA on sensory input. The present study was initiated to study the effects of acute and chronic MDMA on locomotor activity and sensory evoked field potential from freely behaving rats previously implanted with permanent electrodes in the prefrontal cortex (PFC). The main findings of this study are that: (1) acute MDMA augments locomotor behavior and attenuates the incoming sensory input, (2) chronic treatment of MDMA elicits behavioral sensitization, (3) chronic administration of MDMA results in attenuation of the baseline activity of the sensory evoked field potential, and (4) administration of rechallenge MDMA result in enhancement of the PFC sensory evoked field potential.
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| http://dx.doi.org/10.1016/j.brainres.2009.09.048 | DOI Listing |
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