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Factors influencing bloodstream infections after immunosuppressive therapy in patients with aplastic anemia: a logistic regression analysis.
Am J Transl Res
October 2024
Hospital Office, People's Hospital of Zitong County No. 202 Jinniu Avenue Middle Section, Zitong County, Mianyang 622150, Sichuan, China.
Objective: To analyze the risk factors for bloodstream infection after immunosuppressive therapy in patients with aplastic anemia using logistic regression.
Methods: A retrospective analysis was conducted on the clinical data from 70 patients with aplastic anemia admitted to the People's Hospital of Zitong County and the Infectious Disease Hospital in Jiangyou City from March 2011 to March 2023. Patients were divided into two groups based on whether they developed an infection after treatment: the infection group (n = 18) and the non-infection group (n = 52).
Clinical correlates of a high cardiorespiratory risk score for very low birth weight infants.
Pediatr Res
September 2024
Department of Pediatrics, Division of Neonatology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Background: A pulse oximetry warning system (POWS) to analyze heart rate and oxygen saturation data and predict risk of sepsis was developed for very low birth weight (VLBW) infants.
Methods: We determined the clinical correlates and positive predictive value (PPV) of a high POWS score in VLBW infants. In a two-NICU retrospective study, we identified times when POWS increased above 6 (POWS spike).
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis.
Front Immunol
July 2024
Laboratório de Pesquisa Clínica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.
Background: The impact of previous SARS-CoV-2 infection on the systemic immune response during tuberculosis (TB) disease has not been explored.
Methods: An observational, cross-sectional cohort was established to evaluate the systemic immune response in persons with pulmonary tuberculosis with or without previous SARS-CoV-2 infection. Those participants were recruited in an outpatient referral clinic in Rio de Janeiro, Brazil.
Flow cytometry-based method using diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease.
Tuberculosis (Edinb)
July 2024
Department of Respiratory Medicine of the First Faculty of Medicine Charles University, Thomayer University Hospital, Prague, Czech Republic.
Authors present a pilot study of the development of innovative flow cytometry-based assay with a potential for use in tuberculosis diagnostics. Currently available tests do not provide robust discrimination between latent tuberculosis infection (TBI) and tuberculosis disease (TB). The desired application is to distinguish between the two conditions by evaluating the production of a combination of three cytokines: IL-2 (interleukin-2), IFNɣ (interferon gamma) and TNFɑ (tumor necrosis factor alpha) in CD4 and CD8 T cells.
View Article and Find Full Text PDFBackground: We aimed to explore the values of D-dimer (D-D), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and routine blood indicators in the perioperative treatment of patients with orthopedic trauma.
Methods: A total of 170 patients treated from January 2019 to May 2022 were enrolled and assigned into an infection group (n = 71) and a non-infection group (n = 99) according to whether they had infection in the perioperative period. The levels of D-D, CRP, ESR, and routine blood indicators were detected, and their correlations with perioperative infection were analyzed.
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