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Common Benign Bone Lesions and Return to Sports: A Case Report and Scoping Review.
Am J Sports Med
January 2025
University of Alabama at Birmingham, Birmingham, Alabama, USA.
Background: Benign bone lesions are a common incidental finding in athletes during workup for musculoskeletal complaints, and athletes are frequently advised to halt participation in contact sports. There are no current guidelines to assist clinicians in referring patients with these lesions to a subspecialist or in advising athletes on the safety of returning to sport.
Purpose: To assist sports medicine physicians in appropriate referral for patients with benign bone lesions through presentation of a literature review and the case of an adolescent athlete with a benign bone lesion in a location with a significant fracture risk.
Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma.
Contemp Oncol (Pozn)
October 2024
Department of Pathology, Chair of Oncology, Medical University of Łódź, Łódź, Poland.
Article Synopsis
- Chondromyxoid fibromas (CMF) are rare benign bone tumors that can cause symptoms like pain or swelling, but may also be asymptomatic, making diagnosis difficult.
- This report details a case of a 66-year-old woman whose tumor was initially misdiagnosed as a neuroma, later thought to be a low-grade osteosarcoma after surgery.
- Ultimately, advanced testing confirmed it was a chondromyxoid fibroma, highlighting the need for thorough diagnostic approaches for accurate identification of these tumors.
Intra-Articular Osteochondroma in the Elbow: Diagnosis and Surgical Treatment in an 8-Year-Old Boy.
Am J Case Rep
October 2024
College of Medicine, King Khalid University, Abha, Saudi Arabia.
Article Synopsis
- Osteochondroma is the most prevalent benign bone tumor that can cause pain and restricted movement, especially in children, and this report examines a specific case involving an 8-year-old boy with an intra-articular osteochondroma in his elbow.
- The boy experienced persistent pain and limited motion in his elbow, leading to surgical intervention where a mass was successfully excised, and pathology confirmed the diagnosis.
- The report emphasizes the necessity of surgical removal and histopathological examination to correctly diagnose osteochondroma and differentiate it from other potential intra-articular conditions.
Giant Chondromyxoid Fibroma Associated With Epileptic Seizures: A Case Report.
Cureus
October 2024
Department of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
This case report presents an exceedingly rare instance of skull base chondromyxoid fibroma (CMF) managed surgically. Chondromyxoid fibromas are very rare tumors (<1% of benign bone tumors), the occurrence in the skull area being even more rare. The location of tumors at the skull base makes their surgical resection extremely challenging, usually resulting in subtotal resection (STR).
View Article and Find Full Text PDFDetection of GRM1 gene rearrangements in chondromyxoid fibroma: a comparison of fluorescence in-situ hybridisation, RNA sequencing and immunohistochemical analysis.
Histopathology
December 2024
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Article Synopsis
- Chondromyxoid fibroma (CMF) is a rare and usually harmless bone tumor that mostly affects young adults, and figuring it out can be tricky.
- Researchers looked at the GRM1 gene, which is linked to this tumor, to see if it has changes, fusions, or too much of its protein in CMF cases.
- They found that most cases had extra GRM1 protein, and about 75% showed changes in the gene, but they didn't find any gene fusions, making it hard to use certain testing methods for diagnosing CMF.
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