Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans.

Kiem Vu Babette Weksler Ignacio Romero Pierre-Olivier Couraud Angie Gelli

Eukaryot Cell

Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA.

Published: November 2009

Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772405	PMC
http://dx.doi.org/10.1128/EC.00240-09	DOI Listing

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