AI Article Synopsis
- Regulatory T cells (Tregs) are essential for maintaining immune balance, and their dysfunction can lead to conditions like atherosclerosis.
- Researchers vaccinated LDL receptor deficient mice with dendritic cells that contained Foxp3 mRNA and found that this vaccination reduced Tregs and increased atherosclerotic lesions.
- The study highlights the protective role of Foxp3-expressing Tregs in atherosclerosis, suggesting a new avenue for potential treatments targeting these cells.
Article Abstract
Objective: Regulatory T cells are crucial for immune homeostasis and an impaired regulatory T cell function results in many pathological conditions. Regulatory T cells have already been described to be protective in atherosclerosis. However the exact contribution of Foxp3-expressing natural regulatory T cells in atherosclerosis has not been elucidated yet.
Methods And Results: In this study we vaccinated LDL receptor deficient mice with dendritic cells which are transfected with Foxp3 encoding mRNA and studied the effect on initial atherosclerosis. Vaccination against Foxp3 resulted in a reduction of Foxp3(+) regulatory T cells in several organs and in an increase in initial atherosclerotic lesion formation. Furthermore we observed an increase in plaque cellularity and increased T cell proliferation in the Foxp3 vaccinated mice.
Conclusion: We further establish the protective role of Tregs in atherosclerosis. The results illustrate the important role for Foxp3-expressing regulatory T cells in atherosclerosis, thereby providing a potential opportunity for therapeutic intervention against this disease.
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| http://dx.doi.org/10.1016/j.atherosclerosis.2009.08.041 | DOI Listing |
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