[Anti-viral effects of Tankejing preparations against influenza virus A].

Objective: To investigate the anti-viral effects of Tankejing preparations (including solutions, dry power inhalation and powder) against influenza virus A in vitro and the relationship between its anti-viral effect and preparations.

Methods: The inhibitive effect of different drug-added ways of Tankejing extracts against human influenza virus A (H3N2) in vitro were assayed by crystallized purple staining method with ribavirin as positive reference drug. Then we compared the anti-viral actions of different kinds of Tankejing preparations. At last, we carried on serum pharmacodynamics to test and verify the effect.

Results: Tankejing extracts had an effect on comprehensive inhibition and an inhibition on virus proliferation after adsorption. When the concentration was 0.062 g/mL, the inhibition rate of solution dry power inhalation and powder were 43.50%, 41.50% and 37.36%, respectively. The anti-viral effect of dry powder inhalation was better than power's in serum pharmacokinetis experiment.

Conclusion: Tankejing preparations display an action against human influenza virus A in vitro. Those preparation with better solubility have greater anti-viral effect.