AI Article Synopsis
- Salivary gland pleomorphic adenomas often show chromosome abnormalities at 8q12, raising questions about their connection to tumor development.
- DNA from eight adenomas with these abnormalities was analyzed for changes in the proto-oncogene c-mos, which is located near the affected area.
- The study found no rearranged c-mos alleles in any of the tumors, only the normal germ-line fragments.
Article Abstract
The frequent occurrence of salivary gland pleomorphic adenomas characterized by clonal structural chromosome abnormalities involving 8q12 raises the question as to how the cytogenetic rearrangements correspond to molecular mechanisms of tumor development. Since the proto-oncogene c-mos maps to this breakpoint region, DNA from eight adenomas with these aberrations was isolated and checked for rearrangements of c-mos after digestion by BamHI, EcoRI and HindIII. In none of the tumors was a rearranged allele besides the germ-line fragments found.
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| http://dx.doi.org/10.1016/0165-4608(90)90138-z | DOI Listing |
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