Background And Objective: Use of potentially inappropriate psychoactive medications (PIPMs) poses a serious threat of falls among elderly nursing home residents. This study was conducted to identify the effects of PIPMs on falls compared with use of other psychoactive medications among elderly US nursing home residents.
Methods: The 2004 National Nursing Home Survey (NNHS) was used as the data source. Logistic regression was performed to ascertain the relationship between elderly residents who fell in the past 30 days and the use of PIPMs as per Beers' criteria in the presence of other risk factors. The data analysis was performed using SAS version 9.1.
Results: The 2004 NNHS database includes data concerning 11 940 elderly residents in 1174 facilities. The mean age of the elderly residents was 84.1 +/- 7.97 years. Residents receiving PIPMs were at an increased risk of falling compared with those receiving other psychoactive medications (odds ratio [OR] = 0.830, p = 0.028) as well as compared with residents not receiving psychoactive medications (OR = 0.624, p < 0.001). In addition, residents' fall risk increased with an increase in the number of impaired activities of daily living (OR = 1.160, p < 0.001). Presence of depressed mood indicators was also identified as an important risk factor (OR = 1.256, p < 0.001). Use of bedrails had a protective effect on residents' fall risk (OR = 0.714, p < 0.001). Demographic factors such as male sex and White race were also significant fall-risk factors.
Conclusion: Prevention of falls in elderly nursing home residents remains a challenge. Despite the recommendations of prescribing guidelines, PIPMs are still prescribed to elderly nursing home residents. Access to appropriate psychoactive medications should be ensured. Residents with the identified risk factors should be closely monitored. Further research should be pursued to evaluate the impact on falls of potentially inappropriate medications in other therapeutic categories.
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http://dx.doi.org/10.2165/11316800-000000000-00000 | DOI Listing |
Cureus
December 2024
Psychiatry, Drexel University College of Medicine, West Reading, USA.
Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by severe, disproportionate pain relative to an inciting event. The disorder's pathophysiology is complex, involving both central and peripheral nervous system alterations, alongside genetic, inflammatory, and psychological factors. Using data from TriNetX, this study investigated the impact of analgesic and adjuvant therapies on psychiatric outcomes in CRPS patients.
View Article and Find Full Text PDFMolecules
December 2024
Faculty of Food Science and Engineering, Dunarea de Jos University of Galati, 111 Domneasca Street, 800201 Galati, Romania.
The growing demand for plant-based protein and natural food ingredients has further fueled interest in exploring hemp seeds ( L.) as a sustainable source of and nutrition. In addition to the content of proteins and healthy fats (linoleic acid and alpha-linolenic acid), hemp seeds are rich in phytochemical compounds, especially terpenoids, polyphenols, and phytosterols, which contribute to their bioactive properties.
View Article and Find Full Text PDFHarm Reduct J
January 2025
Department of Psychiatry and Neurosciences, CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Background: Gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (BD) have become a significant concern due to the increase in their recreational use and the high risks associated with it (e.g., overdose, addiction, life-threatening withdrawal syndromes).
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January 2025
Interdisciplinary Cooperation for Ayahuasca Research and Outreach (ICARO), School of Medical Sciences, State University of Campinas, Campinas, Brazil.
This study is a survey-type, cross-sectional study conducted in Brazil ( = 517), with online data collection taking place from April to June 2022. The main objective of this study was to evaluate the death anxiety in users and non-users of psychedelics. To this end, we also assessed the validity and reliability of the Death Anxiety Scale in Brazil.
View Article and Find Full Text PDFEur J Hosp Pharm
January 2025
Pharmacology & Therapeutics, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain
Background: Tachyphylaxis is the rapid development of drug tolerance following repeated administration.
Objectives: To evaluate the United States Food and Drug Administration Adverse Event Reporting System (USFDA AERS) data for drugs significantly associated with tachyphylaxis using disproportionality analysis.
Methods: Disproportionality analysis was used for detecting safety signals for identifying drugs associated with tachyphylaxis.
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