AI Article Synopsis
- The study tested the delivery of functional nanomaterials, like gold and silver nanoparticles and carbon nanotubes, to two cell lines, showing quick uptake and significant changes in cell shape and size.
- The highest cell death was observed with carbon nanotubes, which increased with higher concentrations, indicating their strong impact on cellular health.
- Combining these nanomaterials with chemotherapy drugs dramatically increased cell death rates (100-300%), suggesting potential for new cancer treatments that use both types of agents together.
Article Abstract
Functional nanomaterials that included gold, silver nanoparticles and single wall carbon nanotubes were delivered to two cell lines (MLO-Y4 osteocytic cells and HeLa cervical cancer cells) in various concentrations. The cells were found to uptake the nanomaterials in a relatively short time, a process that significantly affected the shape and the size of the cells. The percentage of cellular death, due to the delivery of these nanomaterials, was found to be the highest for carbon nanotubes and increased gradually with the concentration of these nanostructures. Moreover, when the nanomaterials were delivered to the cells combined with commonly used chemotherapeutic agents such as etoposide or dexamethasone, the number of the cells that died increased significantly (100-300%) as compared with the case when only the nanomaterials or the chemotherapeutic agents were delivered. The experimental results were confirmed by Caspase 3 studies, indicating a strong interaction between the nanomaterials used in this study and the protein structure of the cells, which allowed a more effective action of the apoptotic agents. These findings could be the foundation of a new class of cancer therapies that are composed of both chemotherapeutic agents and nanomaterials.
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| http://dx.doi.org/10.1002/jat.1475 | DOI Listing |
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