AI Article Synopsis
- - Researchers created modified Sindbis viruses to display different versions of the protective antigen (PA) from Bacillus anthracis, the bacterium that causes anthrax.
- - These modified viruses successfully triggered the production of PA-specific antibodies in mice, indicating a strong immune response.
- - When the mice were vaccinated with these engineered viruses, they showed some protection against a deadly strain of anthrax spores, and the vaccine worked even better when combined with the antibiotic ciprofloxacin.
Article Abstract
Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772374 | PMC |
| http://dx.doi.org/10.1128/CVI.00173-09 | DOI Listing |
Publication Analysis
Top Keywords
recombinant sindbis
8
protective antigen
8
antigen bacillus
8
bacillus anthracis
8
recombinant viruses
8
viruses induced
8
recombinant
4
sindbis virus
4
virus vectors
4
vectors designed
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!