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Quantifying the Molecular Properties of the Elk Chronic Wasting Disease Agent with Mass Spectrometry.
Pathogens
November 2024
Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA.
Article Synopsis
- Chronic wasting disease (CWD) is a prion disease that impacts both wild and farmed elk, where infectious proteins cause normal proteins to misfold.
- A study used mass spectrometry to analyze prion proteins from elk inoculated with CWD, focusing on various peptides to measure prion quantity and composition.
- Results indicated differing amounts of prion proteins in the elk's brain tissue and highlighted the presence of methionine oxidation, demonstrating how mass spectrometry can help identify prion strains on a molecular level.
Association between proton pump inhibitors and dementia risk: a Mendelian randomization study.
Sci Rep
November 2024
Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
Numerous observational studies suggest associations between proton pump inhibitors (PPIs) and dementia, but causal relationships remain uncertain. Using large-scale genome-wide association study (GWAS) data, we performed univariable Mendelian randomization (UVMR) analysis to assess the causality between five PPI types, and all-cause dementia and its five subtypes. Confounders were controlled through multivariable MR (MVMR) analysis to isolate PPIs' direct effects on dementia.
View Article and Find Full Text PDFNotable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles .
Xenobiotica
October 2024
Department of Pharmacy, The First People's Hospital of Yunnan Province, Kunming, China.
The drug-drug interaction (DDI) and CYP2C19 genetic variation can lead to a high blood concentration of voriconazole. CYP2C19 is a highly genetically polymorphic enzyme, and CYP2C19*2 is more frequent among Asians associated with reduced metabolism of drugs. Clinical study found that co-administration with omeprazole significantly increased voriconazole concentrations and there was an additive effect in CYP2C19*2 allele.
View Article and Find Full Text PDFUnderstanding Drug Exposure and Trichuris trichiura Cure Rates: A Pharmacometric Approach for Albendazole-Ivermectin Co-medication in Tanzania and Côte d'Ivoire.
Drugs R D
June 2024
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Allschwil Switzerland, University of Basel, Basel, Switzerland.
Background And Objective: Trichuriasis caused by the human whipworm Trichuris trichiura poses a significant public health concern. Albendazole-ivermectin co-medication is currently the most effective treatment. Studies conducted in Tanzania and Côte d'Ivoire unveiled differences in efficacy for albendazole-ivermectin combination therapy in both countries.
View Article and Find Full Text PDFEffect of MDR1 C3435T and CYP2C19 genetic polymorphisms on the outcome of Helicobacter pylori eradication treatment in children with gastritis and peptic ulcer, Vietnam.
BMC Pediatr
July 2024
Department of Pediatrics, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Background: Helicobacter pylori eradication therapy based on antimicrobial susceptibility in Vietnamese children currently get low efficiency. There are causes of treatment failure, among host genetic factors namely MDR1 C3435T and CYP2C19 affect the absorption and metabolism of proton pump inhibitors - a crucial component of eradication therapy. The study aimed to investigate the effect of MDR1 C3435T and CYP2C19 genetic polymorphisms on the cure rate.
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