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Key Risk Factors, Sex Differences, and the Influence of High-Intensity Exercise on Colorectal Carcinogenesis: A 10-Year Cohort Study Based on 1,120,377 Individuals from the NHISS Data.
Curr Oncol
November 2024
School of Kinesiology, Yeungnam University, 280, Daehak-ro, Gyeongsan 38541, Gyeongbuk, Republic of Korea.
Colorectal cancer (CRC) is the third most common cancer globally. Therefore, this study aims to examine data from the National Health Insurance Sharing Service (NHISS) to investigate factors influencing colon cancer incidence, focusing on key variables and optimal cutoff points. The patient cohort from the NHISS database included 1,120,377 individuals aged 1-85 years.
View Article and Find Full Text PDFPathogenicity and virulence of : A paradigm of chronic infection.
Virulence
December 2025
The Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
Infection with is one of the most common infections of mankind. Infection typically occurs in childhood and persists for the lifetime of the host unless eradicated with antimicrobials. The organism colonizes the stomach and causes gastritis.
View Article and Find Full Text PDFMULTIPLE MUSHROOM-LIKE GROWING CYLINDROMAS OF THE SCALP (TURBAN TUMOR) IN A PATIENT WITH BROOKE-SPIEGLER SYNDROME: UNIQUE MANIFESTATION IN A BULGARIAN PATIENT.
Georgian Med News
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1Onkoderma - Clinic for Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
Cutaneous cylindromas are rare, slow-growing adnexal tumors commonly found on the capillitium or face. When located on the capillitium, they can cluster together, forming a headgear-like structure that gives the characteristic "turban" appearance. Brooke-Spiegler syndrome, an autosomal dominant condition, is typically benign, though malignant transformation can occur.
View Article and Find Full Text PDF[Evaluation of the toxicity of perfluorooctanoic acid toward human colorectal cancer cells using multi-dimensional approaches].
Se Pu
January 2025
School of Marine Sciences, Sun Yat-sen University, Zhuhai 519082, China.
Article Synopsis
- Human exposure to perfluorooctanoic acid (PFOA) can lead to ulcerative colitis, but the mechanisms of its toxicity in intestinal cells remain unclear.
- Researchers studied the effects of PFOA on human colorectal cancer cells (HCT116) by examining cell viability, mitochondrial activity, and gene expression related to metabolism.
- They found that 300 μmol/L of PFOA significantly reduced the viability of HCT116 cells and altered metabolic gene expression, while lower concentrations (50 μmol/L) increased mitochondrial respiratory activity.
- The study suggests that mitochondrial activity could indicate PFOA's effects, and specific genes could play a role in the development of ulcerative colitis linked to PFOA exposure
Diabetic ulcer with cutaneous squamous cell carcinoma: A case report.
World J Clin Oncol
December 2024
Department of Vascular Surgery in Traditional Chinese Medicine, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China.
Background: Chronic skin ulcers are a risk factor for the development of skin tumors. In patients with diabetes, chronic refractory ulcers may also contribute to higher susceptibility to skin tumors. Timely surgical removal of chronic and nonhealing diabetic foot ulcers can effectively prevent progression to squamous cell carcinoma.
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