Purpose: To describe ocular findings for a 34-year-old man with chronic solar retinopathy using high-speed ultrahigh-resolution (UHR) optical coherence tomography (OCT).
Methods: Fundus photography, fluorescein angiography, and Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) were performed. A high-speed UHR OCT prototype developed in our ophthalmology clinic was used to obtain detailed images of the retina.
Patients: Two eyes of one patient with chronic solar retinopathy were studied.
Results: Both Stratus OCT and high-speed UHR OCT demonstrated foveal thinning bilaterally. In addition, high-speed UHR OCT showed distinct hyporeflective disruptions in the photoreceptor inner segment/outer segment junction and photoreceptor outer segments bilaterally. En face OCT images from three-dimensional OCT data sets revealed hyporeflective regions of photoreceptor atrophy in the outer retina.
Conclusions: High-speed UHR OCT showed more detail than standard OCT, and findings were consistent with histopathologic and ultrastructural features that have been reported previously. Solar retinopathy should be studied further with high-speed UHR OCT to determine the short- and long-term effects of solar radiation damage.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743270 | PMC |
| http://dx.doi.org/10.1097/ICB.0b013e3181506993 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band.
Biomed Opt Express
April 2022
Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02140, USA.
Ultrahigh resolution optical coherence tomography (UHR-OCT) can image microscopic features that are not visible with the standard OCT resolution of 5-15 µm. In previous studies, high-speed UHR-OCT has been accomplished within the visible (VIS) and near-infrared (NIR-I) spectral ranges, specifically within 550-950 nm. Here, we present a spectral domain UHR-OCT system operating in a short-wavelength infrared (SWIR) range from 1000 to 1600 nm using a supercontinuum light source and an InGaAs-based spectrometer.
View Article and Find Full Text PDFHigh-Speed, Ultrahigh-Resolution Spectral-Domain OCT with Extended Imaging Range Using Reference Arm Length Matching.
Transl Vis Sci Technol
June 2020
Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Purpose: To develop high-speed, extended-range, ultrahigh-resolution spectral-domain optical coherence tomography (UHR SD-OCT) and demonstrate scan protocols for clinical retinal imaging.
Methods: A UHR SD-OCT operating at 840-nm with 150-nm bandwidths was developed. The axial imaging range was extended by dynamically matching reference arm length to the retinal contour during acquisition.
Advances in Corneal Imaging: Current Applications and Beyond.
Asia Pac J Ophthalmol (Phila)
April 2019
From the Department of Ophthalmology, The University of Hong Kong, Hong Kong; Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong; and Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Recent advances in corneal imaging have allowed for more objective diagnosis and disease monitoring, as well as provided valuable guidance for treatment progress. However, there has been limited literature providing comprehensive insight into advances across different imaging modalities. The aim of this review was to provide a brief summary of significant advances in the field of corneal imaging over the past 5 years.
View Article and Find Full Text PDFVisualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT.
Lasers Surg Med
March 2017
Departmentof Electrical Engineering, Columbia University, New York, New York, 10027.
Background And Objective: Breast cancer is one of the most common cancers, and recognized as the third leading cause of mortality in women. Optical coherence tomography (OCT) enables three dimensional visualization of biological tissue with micrometer level resolution at high speed, and can play an important role in early diagnosis and treatment guidance of breast cancer. In particular, ultra-high resolution (UHR) OCT provides images with better histological correlation.
View Article and Find Full Text PDFQuantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography.
J Biophotonics
April 2016
Department of Dermatology, Taipei City Hospital, Renai Branch, Taipei, Taiwan.
Non-invasive and quantitative estimations for the delineation of sub-surface tumor margins could greatly aid in the early detection and monitoring of the morphological appearances of tumor growth, ensure complete tumor excision without the unnecessary sacrifice of healthy tissue, and facilitate post-operative follow-up for recurrence. In this study, a high-speed, non-invasive, and ultra-high-resolution spectral domain optical coherence tomography (UHR-SDOCT) imaging platform was developed for the quantitative measurement of human sub-surface skin mass. With a proposed robust, semi-automatic analysis, the system can rapidly quantify lesion area and shape regularity by an en-face-oriented algorithm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!