AI Article Synopsis

  • A 46-year-old male non-Saudi resident of Makkah presented with unusual symptoms, including gastroenteritis and bloody diarrhea, rather than the typical malaria symptoms like fever.
  • Initial tests showed anemia and a negative blood film for malaria, despite the patient’s recent travel to Pakistan, which is an endemic area for the disease.
  • After several days and a repeat blood examination, a sexual form of Plasmodium falciparum was finally detected, highlighting the need for repeated malaria testing in patients with recent travel history to endemic regions.

Article Abstract

An unusual case of malaria presented with gastroenteritis and bloody diarrhoea in a 46-year-old male. The patient was a non-Saudi resident of Makkah, Saudi Arabia. Fever was not the presenting complaint, and the patient had not experienced any chills or sweating. He gave history of recent travel to Pakistan. Initial laboratory investigations showed anemia, thrombocytopenia, normal liver function, and negative blood film for malaria. His widal, Brucella, and dengue serology was negative. Endoscopic examination showed gastroenteritis. On the fifth day of admission, a sexual form of Plasmodium falciparum on peripheral smear was reported by chance. Malaria was misdiagnosed because of initial negative blood film which may have been due to false microscopy or a long period between exposures and positive blood film. We concluded that a repeat blood film for malaria at 12- to 24-hour intervals for 48 to 72 hours is cost effective when a patient has recently travelled to an endemic area.

Download full-text PDF

Source
http://dx.doi.org/10.3855/jidc.58DOI Listing

Publication Analysis

Top Keywords

blood film
16
case malaria
8
plasmodium falciparum
8
negative blood
8
film malaria
8
malaria
5
misdiagnosis imported
4
imported case
4
malaria caused
4
caused plasmodium
4

Similar Publications

Fibrin film on clots is increased by haematocrit but reduced by inflammation: implications for platelets and fibrinolysis.

J Thromb Haemost

January 2025

Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

Background: Blood clot formation, triggered by vascular injury, is crucial for haemostasis and thrombosis. Blood clots are composed mainly of fibrin fibres, platelets and red blood cells (RBCs). Recent studies show that clot surface also develops a fibrin film, which provides protection against wound infection and retains components such as RBCs within the clot.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on creating a new drug delivery system using dual-ligand-modified liposomes to target glioma, with the goal of overcoming the blood-brain barrier and improving drug effectiveness.
  • Researchers used a specific technique to prepare liposomes that co-load a photosensitizer (ICG) and a chemotherapeutic drug (MTO), and tested their properties and ability to penetrate the blood-brain barrier while targeting glioma cells.
  • Results showed that the modified liposomes were stable, capable of effectively penetrating the blood-brain barrier, concentrating in glioma cells, and exhibited strong anti-tumor effects, highlighting their potential in improving glioma treatment.
View Article and Find Full Text PDF

In treating type 2 diabetes, avoiding glucose reabsorption (glucotoxicity) and managing hyperglycemia are also important. A metabolic condition known as diabetes (type-2) is characterized by high blood sugar levels in comparison to normal Bilosomes (BLs) containing Dapagliflozin (Dapa) were formulated, optimized, and tested for oral therapeutic efficacy in the current investigation. Used the Box Behnken design to optimize the Dapa-BLs, formulated via a thin-film hydration technique.

View Article and Find Full Text PDF

Silver nanowire/gold nanosphere binary plasma-assembled membranes for sensitive SERS detection of homocysteine.

Mikrochim Acta

December 2024

School of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, Fujian, 350108, China.

Silver nanowire (Ag NW)/gold nanosphere (Au NS) binary plasma films were prepared using plasma coupling between Ag NWs and Au NSs. The plasma films formed by combining these two noble metals showed better sensitivity for SERS detection with a minimum detection concentration of 10 M for R6G compared to pure Ag NWs or Au NSs. After rational optimisation of the substrate preparation process, the substrate showed good homogeneity, reproducibility and stability.

View Article and Find Full Text PDF

Autologous blood therapy has emerged as a promising modality in managing ocular surface disorders. This review provides a comprehensive overview of the current literature regarding the use of autologous blood in ocular surface disorders, encompassing its physiological basis, clinical applications, techniques, challenges, and future perspectives. The ocular surface, comprising the cornea, conjunctiva, and tear film, plays a critical role in maintaining visual function, and its disruption can lead to various pathological conditions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!