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Acid-responsive aggregated carrot-derived nanoantioxidants alleviate oxidative stress and restore osteoblast activity.
J Nanobiotechnology
March 2025
Second Clinical Medical College, School of Pharmacy and Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan, Shanxi, 030001, People's Republic of China.
Background: Excessive generation of reactive oxygen species is a hallmark of the osteoporotic bone microenvironment, which leads to the damage of mitochondrial function and the deactivation of osteoblasts. Fruits and vegetables are rich sources of antioxidants, which play a key role in scavenging free radicals and maintaining the body's homeostasis.
Results: Herein, we have developed a type of vesicle coming from carrots as nanoantioxidants to counteract oxidative stress and restore the vitality of osteoblasts for reversing osteoporosis.
Novel immunotherapy combinations in head and neck squamous cell carcinoma.
Curr Opin Oncol
February 2025
University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Purpose Of Review: Relapsed or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a deadly disease that historically was treated with palliative chemotherapy-based regimens. Since 2019, immunotherapy-based regimens have become the standard of care for 1st line treatment in this disease. Over the last several years, there have been numerous studies conducted with novel combination therapies for R/M HNSCC but there has not yet been a new standard of care.
View Article and Find Full Text PDFShifting Between Models of Mind: New Insights Into How Human Minds Give Rise to Experiences of Spiritual Presence and Alternative Realities.
Top Cogn Sci
March 2025
Department of Anthropology, Stanford University.
Phenomenal experiences of immaterial spiritual beings-hearing the voice of God, seeing the spirit of an ancestor-are a valuable and largely untapped resource for the field of cognitive science. Such experiences, we argue, are experiences of the mind, tied to mental models and cognitive-epistemic attitudes about the mind, and thus provide a striking example of how, with the right combination of mental models and cognitive-epistemic attitudes, one's own thoughts and inner sensations can be experienced as coming from somewhere or someone else. In this paper, we present results from a large-scale study of U.
View Article and Find Full Text PDFThe Hard Road Ahead for State Public Health Departments.
JAMA Health Forum
March 2025
Department of Health Policy, Stanford School of Medicine, Stanford University, Stanford, California.
Impact of harassment and bullying of forensic scientists on work performance, absenteeism, and intention to leave the workplace in the United States.
Forensic Sci Int Synerg
June 2025
Department of Physiology, 10833 Le Conte Avenue, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, 90095, USA.
The purpose of this study was to investigate, for the first time, the extent and nature of harassment and bullying in forensic science laboratories associated with law enforcement in the United States. We hypothesized that the most common harassment would be that of male sworn civil servants targeting women non-sworn forensic scientists. Further, we assessed whether levels of harassment were associated with workplace performance, absenteeism, and intention to leave.
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