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Influence of the cumulative effect of zoledronic acid on periodontal microcirculation in rats.
Oral Maxillofac Surg
December 2021
First Pavlov State Medical University of St. Petersburg, L'va Tolstogo str., 6-8, Saint Petersburg, Russian Federation, 197022.
Purpose: To evaluate the effect of repeated administration of zoledronic acid (ZA) on the development and severity of osteonecrosis of the jaws.
Methods: In the experiment, 36 rats were used, which were divided into 4 groups: group 1 was injected with saline for 6 weeks, group 2 was injected with ZA once, group 3 was injected zoledronic acid for 3 weeks once a week, group 4 was injected with ZA for 6 weeks once a week. While taking medications, the tooth was removed.
Nitrogen-Containing Bisphosphonates Are Associated With Reduced Risk of Pneumonia in Patients With Hip Fracture.
J Bone Miner Res
September 2020
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
The objective of this work was to study the risk of pneumonia and pneumonia mortality among patients receiving nitrogen-containing bisphosphonates (N-BPs), non-N-BP anti-osteoporosis medications, and no anti-osteoporosis medications after hip fracture. We studied a historical cohort using a population-wide database. Patients with first hip fracture during 2005-2015 were identified and matched by time-dependent propensity score.
View Article and Find Full Text PDFMitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors.
Bone Res
March 2020
1National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD USA.
It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the jaw (ONJ) was preceded by phosphorus necrosis of the jaw, ca. 1860.
View Article and Find Full Text PDFFailure to access prescribed pharmaceuticals by older patients with chronic conditions.
Aust Health Rev
April 2020
Centre for Health Economics Research and Evaluation, University of Technology Sydney, Level 2, Building 5 Block D, 1-59 Quay Street, Haymarket, NSW 2000, Australia. Email:
Objective Medication adherence is a significant public health concern. Australian studies of statins show patients facing the highest copayments are the least likely to be adherent. This study examined whether the association identified between adherence and costs for statins also applies to a wider group of medications prescribed for Australian patients with chronic conditions.
View Article and Find Full Text PDFEffect of teriparatide (rh-PTH 1-34) versus bisphosphonate on the healing of osteoporotic vertebral compression fracture: A retrospective comparative study.
BMC Musculoskelet Disord
April 2017
Department of Orthopaedic Surgery, Hokkaido University, N15 W7 Kita-ward, Sapporo, Hokkaido, 060-8638, Japan.
Background: Teriparatide (recombinant human parathyroid hormone 1-34) is increasingly used for the treatment of severe osteoporosis because it stimulates bone formation and may potentially enhance fracture healing. The objective of this study was to investigate the effects of teriparatide versus a bisphosphonate on radiographic outcomes in the treatment of osteoporotic vertebral compression fractures (OVCF).
Methods: A total of 98 patients undergoing non-operative treatment for recent single-level OVCF were reviewed retrospectively.
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