Despite the prevalence of endometriosis in the human population, there is a shortage of animal models for studying it. The authors describe the development of a swine model of endometriosis that allows researchers to evaluate laparoscopic techniques and instruments for diagnosing and treating the condition.
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Recombinant probiotic Escherichia coli delivers the polymeric protein of swine influenza virus for protection.
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Swine influenza virus invades the host through the respiratory mucosa, which severely restricts the development of the pig breeding industry. To construct monomeric and trimeric vaccines, we developed recombinant Escherichia coli Nissle 1917 (EcN) strains that express the receptor binding site (RBS) of the hemagglutinin (HA) antigen from H1N1 swine influenza virus. After the mucosal immunization of mice, we found that probiotics activated CD40 and CD86 in DCs and increased the levels of IL-4 and IFN-γ secretion by T cells.
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Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
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