Szutkowska et al. demonstrate that zeta-crystallin plays an essential role in the stabilization of the Na(+)/K(+)/2Cl(-) cotransporter mRNA in the medullary thick ascending limb. However, differential effects of experiments using small interfering RNA to knock down zeta-crystallin in proximal tubule and thick ascending limb cells suggest that additional proteins must contribute to the rapid turnover and selective stabilization of the various mRNAs during metabolic acidosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814062 | PMC |
| http://dx.doi.org/10.1038/ki.2009.227 | DOI Listing |
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