Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea.

Antimicrob Agents Chemother

Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, South Korea.

Published: January 2010

In vitro activities of colistin and other drugs were tested against 221 Klebsiella pneumoniae isolates that were collected between 2006 and 2007 in nine tertiary care South Korean hospitals from patients with bacteremia. The clonality of colistin-resistant K. pneumoniae (CRKP) isolates was assessed by multilocus sequence typing (MLST). We found that 15 isolates (6.8%) were resistant to colistin. MLST showed that CRKP isolates were nonclonal, with colistin resistance in K. pneumoniae occurring independently and not by clonal spreading.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798536PMC
http://dx.doi.org/10.1128/AAC.00762-09DOI Listing

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