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EFFECT OF DECEPTIVE VERSUS NON-DECEPTIVE PLACEBO ON PSYCHOMOTOR AND COGNITIVE FUNCTIONS IN HEALTHY ADULT HUMAN VOLUNTEERS: AN OPEN-LABEL CROSS-OVER RANDOMIZED CONTROLLED TRIAL.
Psychiatr Danub
December 2024
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
This study was planned to evaluate the effect of a placebo administered with deception vs. without deception on psychomotor and cognitive functions in healthy human volunteers compared to no treatment as placebo responses tend to be circumstantial. An open-label, 3-period, 6-sequence randomized controlled cross-over trial was conducted with 54 participants in a tertiary care center.
View Article and Find Full Text PDFStructural and Functional Projections of the Nucleus Basalis of Meynert and Their Changes After Cognitive Training in Individuals With Mild Cognitive Impairment.
CNS Neurosci Ther
December 2024
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Aims: The nucleus basalis of Meynert (NBM) is a major source of cholinergic innervation in the central nervous system. We aimed to investigate the characteristics of structural and functional alterations in the NBM and its projections in patients with mild cognitive impairment (MCI) and the effects of computerized cognitive training (CCT).
Methods: Forty-five patients with MCI and 45 cognitively unimpaired controls (CUCs) were recruited.
Introduction: Testing cognitive functions in Indians with low literacy and linguistic diversity is challenging. We describe the adaptation process of a comprehensive neurocognitive test battery to suit both literate and illiterate aging rural Indians.
Methods: Following the International Test Commission (ITC) guidelines for cross-cultural adaptation, we adapted the COGNITO battery.
Behavioural, cognitive, and neurophysiological effects of a synbiotic supplementation enriched with pigmented corn extract or cornstarch in drug-naïve children with attention-deficit hyperactivity disorder: a randomised, double-blind, comparison-controlled clinical trial.
Clin Nutr ESPEN
December 2024
Child Psychopathology Unit, Scientific Institute, IRCSS Eugenio Medea, Bosisio Parini LC, Italy.
Background & Aims: Considerable interest has been recently given to the potential role of the gut-brain axis (GBA) -a two-way communication network between the gut microbiota and the central nervous system- in the pathogenesis of attention-deficit hyperactivity disorder (ADHD), suggesting the potential usefulness of probiotic and synbiotic supplementations. In light of the limited available evidence, synbiotic efficacy in ADHD children not taking medications should be clarified. This study aimed to investigate the efficacy of a synbiotic dietary supplementation on fatty acids levels as well as on microbiota composition, behaviour, cognition, and brain function in children with ADHD.
View Article and Find Full Text PDFCOVID-19 may Enduringly Impact Cognitive Performance and Brain Haemodynamics in Undergraduate Students.
Brain Behav Immun
December 2024
Department of Psychology, and Brain Health Research Centre, University of Otago, William James Building, 275 Leith Walk, Dunedin 9054, New Zealand. Electronic address:
To date, 770 million people worldwide have contracted COVID-19, with many reporting long-term "brain fog". Concerningly, young adults are both overrepresented in COVID-19 infection rates and may be especially vulnerable to prolonged cognitive impairments following infection. This calls for focused research on this population to better understand the mechanisms underlying cognitive impairment post-COVID-19.
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