Objective: To estimate the frequency of bacterial vaginosis in women with preterm labour.
Methods: Descriptive cross sectional study carried out in department of Obstetrics and Gynaecology, Military Hospital and Army Medical College Laboratory, Rawalpindi. Non-probability convenience sampling was used and the study was completed in 12 months (from 1st January 2007 - 1st January 2008). Hundred patients in preterm labour were included in the study. An objective diagnosis of the type of discharge was made. The vaginal pH of the discharge was measured. Samples for bacterial culture were obtained. A wet smear of the vaginal secretions was made and examined under the microscope for clue cells followed by Whiff test. All information was recorded on a specially designed proforma and the frequency of patients with bacterial vaginosis was estimated.
Results: A diagnosis of bacterial vaginosis was made in 21% of the patients by the Amsels criteria. However, culture report suggested bacterial vaginosis in 18% of cases with most of the cases (56%) having normal flora. Overall, incidence of infection was 44% in patients with preterm labour.
Conclusion: The frequency of bacterial vaginosis in our study was found to be 21% in preterm labour
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Introduction Bacterial vaginosis (BV) is a risk factor for preterm delivery. Yet, previous studies have found BV treatment ineffective in preventing preterm delivery in unselected population. This study aims to evaluate the effectiveness of BV screening and treatment in reducing the rate of preterm deliveries before 37 weeks in high-risk women.
View Article and Find Full Text PDFPLoS One
January 2025
McMaster Immunology Research Centre and Department of Medicine, McMaster University, Hamilton, ON, Canada.
Background: A dysbiotic vaginal microbiome (VMB) is associated with clinical conditions such as bacterial vaginosis (BV) and an increased risk of human immunodeficiency virus (HIV-1) infection. Considering the high prevalence of BV among African, Caribbean and Black (ACB) women, we conducted a prospective, randomized, open-label phase 1 clinical trial to determine the feasibility, safety and tolerability of administering low-dose estrogen, probiotics or both in combination to improve vaginal health and decrease HIV-1 susceptibility.
Methods: ACB women aged 18-49 from the Greater Toronto Area (GTA) were randomized to one of four study arms: intravaginal estradiol (Estring©; 7.
BMC Pregnancy Childbirth
January 2025
Department of Social Administration & Justice, Faculty of Arts & Social Sciences, Universiti Malaya, Kuala Lumpur, Asbah, Razali, 50603, Malaysia.
Introduction: Bacterial vaginosis (BV) is one of the most common genital tract infections among women of reproductive age. The existence of BV among pregnant women has momentously attracted the attention of both clinicians and the scientific community due to its potential link with adverse clinical outcomes in pregnancy.
Methods: To evaluate the prevalence, risk factors, and adverse outcomes of bacterial vaginosis among pregnant women, a comprehensive systematic review was conducted based on the preferred reporting items for systematic review and meta-analyses (PRISMA) criteria.
Int J Pharm
January 2025
Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133, Milano, Italy.
Targeting the development of a 3D printed reservoir-like vaginal rings (VRs) intended to fulfill the needs of precision medicine, prototypes ensuring prolonged release of metronidazole (MTZ) were preliminary manufactured and tested. Indeed, this drug represents the first-line therapy against bacterial vaginosis, which would especially benefit from convenient as well as easy dose adjustment and from more than 48 h continuous release, thus avoiding barely tolerated and repeated administrations. Starting from a soft thermoplastic elastomer (TPE), hollow ring structures were successfully printed at 190 °C and then extemporaneously filled with drug-loaded, in-situ-crosslinking hydrogel formulations based on alginate (ALG).
View Article and Find Full Text PDFBMC Microbiol
January 2025
Chair of Microbiology, Jagiellonian University Medical College in Krakow, 18 Czysta Street, Cracow, 31-121, Poland.
Background: Aerobic vaginitis (AV) is a state of abnormal vaginal microbiota, which is associated with increased numbers of aerobic, enteric bacteria and inflammation of the vaginal epithelium. Anti-microbial treatment combined with anti-inflammatory therapy could be useful in the treatment of this condition. It is known that calcitriol, the active form of vitamin D, plays an important role in modulating the immune response in several inflammatory diseases.
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