The gain-of-function mutation G648D in UPC2 causes ERG11 up-regulation and increased fluconazole resistance in Candida albicans. In this study, we performed 2-DE and PMF to identify proteomic alterations in an ERG11-overexpressing fluconazole-resistant C. albicans clinical isolate compared with its fluconazole-susceptible parent strain. We identified 23 differentially expressed proteins, and among them, seven became differentially expressed in a C. albicans wild-type strain after the introduction of a UPC2 allele carrying this mutation. These Upc2p-regulated proteins may contribute to fluconazole resistance in C. albicans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/pmic.200900176 | DOI Listing |
Publication Analysis
Top Keywords
candida albicans
8
fluconazole resistance
8
differentially expressed
8
albicans
5
upc2p-associated differential
4
differential protein
4
protein expression
4
expression candida
4
albicans gain-of-function
4
gain-of-function mutation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!