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PcNAC25, a NAC transcription factor of Pugionium cornutum(L.) Gaertn conferring enhanced drought and salt stress tolerances in Arabidopsis.
Sci Rep
January 2025
College of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, 010018, Inner Mongolia, China.
Pugionium cornutum (L.) Gaertn (P. cornutum) has strong tolerance to drought, salt and disease, but the tolerance mechanisms for such stresses in P.
View Article and Find Full Text PDFSelective inhibition of HSF1 expression in the heat shock pathway of keloid fibroblasts reduces excessive fibrosis in keloid.
Arch Dermatol Res
January 2025
Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan, China.
The stress response following burns may be a crucial factor in keloid formation, yet the underlying pathological mechanisms remain to be elucidated. This study initially investigated how heat shock factor 1 (HSF1) and heat shock proteins (HSPs) within the heat shock pathway influence keloid fibrosis, providing insights into the role of the heat shock response in keloid development. This study aims to further elucidate the role of the heat shock pathway in keloid fibrosis and investigate the specific function of HSF1 within this pathway.
View Article and Find Full Text PDFTolerance to multiple abiotic stresses is mediated by interacting CNGC proteins that regulate Ca influx and stomatal movement in rice.
J Integr Plant Biol
January 2025
State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, College of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China.
Members of the cyclic nucleotide-gated channel (CNGC) proteins are reportedly involved in a variety of biotic and abiotic responses and stomatal movement. However, it is unknown if and how a single member could regulate multiple responses. Here we characterized three closely related CNGC genes in rice, OsCNGC14, OsCNGC15 and OsCNGC16, to determine whether they function in multiple abiotic stresses.
View Article and Find Full Text PDFAqueous Proteomic and Metabolomic Profiles in Low-Energy vs High-Energy Femtosecond Laser-Assisted Cataract Surgery.
Invest Ophthalmol Vis Sci
January 2025
Singapore Eye Research Institute, Singapore.
Purpose: To investigate the aqueous proteomics and metabolomics in low-energy and high-energy femtosecond laser-assisted cataract surgery (FLACS).
Methods: In this prospective observational study, 72 patients were randomized to 3 groups: low-energy FLACS, high-energy FLACS, and conventional phacoemulsification (controls). Aqueous was collected after femtosecond laser treatment or at the beginning of surgery (controls).
LMAN2 interacts with HEATR3 to expedite HER2-positive breast cancer advancement and inflammation and Akt/ERK/NF-κB signaling.
Biochem Cell Biol
January 2025
Department of Breast Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, China.
The paper aimed to reveal the impacts and the possible mechanism of action of lectin mannose-binding 2 protein (LMAN2) in HER2-positive breast cancer (BC). The expression, prognostic potential of LMAN2, and the correlation between LMAN2 and HEAT repeat containing 3 (HEATR3) in BC were analyzed in TCGA database. Intact, Mentha, and BioGrid databases predicted LMAN2-HEATR3 interactions.
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