This minireview highlights recent advances of research dedicated to photoswitchable fluorescent nanoparticles and their applications. Recently, several strategies have been developed to synthesize nanoparticles with optically switchable emission properties: either fluorescence on/off or dual-alternating-color fluorescence photoswitching. The underlying mechanisms of fluorescence photoswitching enable many different types of photoswitchable fluorescent nanoparticles to change fluorescence colors, thus validating the basis of the initial photoswitching design. Among all possible applications, the usage of photoswitchable fluorescent nanoparticles to empower super-resolution fluorescence imaging and to label biological targets was subsequently reviewed. Finally, we summarize the important areas regarding future research and development on photoswitchable fluorescent nanoparticles.
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http://dx.doi.org/10.1002/cphc.200900492 | DOI Listing |
Chem Sci
December 2024
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University Wuhan 430079 P. R. China
Developing dithienylethene (DTE)-based fluorescence switches triggered by biocompatible visible light has always been a long-term goal in view of their potential in numerous biological scenarios. However, their practical availability is severely limited by the short visible light (generally less than 500 nm) required for photocyclization, their inability to achieve red or near-infrared emission, and their short fluorescence lifetimes. Herein, we present a novel DTE derivative featuring a dimethylamine-functionalized BF-curcuminoid moiety (NBDC) by using an "acceptor synergistic conjugation system" strategy.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Institute of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Pécs, Honvéd útja 1, H-7624 Pécs, Hungary.
The therapeutical applicability of the anticancer drug phototrexate, a photoswitchable derivative of the antimetabolite dihydrofolate reductase inhibitor methotrexate, highly depends on the stability of its bioactive isomer. Considering that only the configuration of phototrexate is bioactive, in this work, the effect of the molecular environment on the stability of the isomer of this drug has been investigated. UV-vis absorption and fluorescence-based solvent relaxation methods have been used.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The, Netherlands.
The mobility of proteins in the bilayer membrane is affected by (local) changes in lipid environment, which is important to their biological functioning. Artificial molecular systems that-to some extent-imitate tasks of membrane-embedded proteins are increasingly developed, however, they are usually controlled through responsive units in their core structure. Here we present an alternative approach based on an amphiphilic stiff-stilbene derivative that enables control of membrane fluidity by light.
View Article and Find Full Text PDFJ Agric Food Chem
December 2024
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Photopharmacology, an emerging interdisciplinary field, enables precise modulation of target biological activity by employing light-controllable photoswitchable molecules. The research on nicotinamidase (Naam), a recently identified target molecule for pesticides, remains relatively underexplored. Therefore, based on the structure of its inhibitor Flonicamid, we designed and synthesized a series of photopharmacological ligands (FAB) by incorporating a light-controllable azobenzene switch, further investigating their effects on insect behavior and activity.
View Article and Find Full Text PDFNanoscale
December 2024
Soft Foundry Institute, College of Engineering, Seoul National University, Seoul, Republic of Korea.
Brookite exists as the metastable phase of titania and often mediates the transformation of anatase to rutile. The photocatalytic competence of brookite relative to polymorphs anatase and rutile has generally been considered structurally and energetically unfavourable for reasons that remain largely unknown and unchallenged. However, the process of phase transformation and performance related cooperativity among all three polymorphs has recently unlocked alternative directions for exploring brookite photovoltaics.
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