Genital involvement is an unusual manifestation of histoplasmosis. We report a case of histoplasmosis presenting as granulomatous epididymo-orchitis and review 4 cases reported in the literature. Diagnosis of this infection is suggested by a compatible clinical picture and results of specific serology or antigen testing, but confirmation ultimately requires analysis of pathologic specimens. Surgical drainage or resection of involved tissues and systemic antifungals typically result in resolution of infection and improved outcomes.
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Article Synopsis
- The study explores the relationship between pancytopenia (a decrease in blood cells) and disseminated histoplasmosis, noting that this connection is rarely documented in existing literature.
- The authors reviewed 72 cases worldwide, primarily from the Americas, finding that many patients had underlying conditions, such as HIV and haemophagocytic lymphohistiocytosis.
- Recovery rates were relatively high at 73.6%, but significant mortality was attributed to diagnostic delays and complications, indicating that early recognition of pancytopenia may be crucial for better patient outcomes.
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