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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence.
AMB Express
January 2025
Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Candida albicans is a commensal fungus that naturally inhabits the vagina. However, overgrowth of C. albicans can result in vulvovaginal candidiasis (VVC), one of the most prevalent fungal infections affecting women.
View Article and Find Full Text PDFCalcination-Induced Tight Nano-Heterointerface for Highly Effective Eradication of Rib Fracture-Related Infection by Near-Infrared Irradiation.
ACS Appl Mater Interfaces
January 2025
School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.
Rib fracture-related infection is a challenging complication of thoracic trauma due to the difficulty of treating it with antibiotics alone and the need for a second operation to remove the infected fixator and sterilize the surrounding infected tissue. In this study, inspired by the photocatalytic performance of and ion release from silver-based materials, including AgPO and AgS, a hybrid AgPO-AgS heterojunction was prepared based on anion exchange and a one-step calcination process to design a nonantibiotic coating aimed at preventing and treating rib fracture-related infection with short-term 808 nm near-infrared irradiation. Calcination at 250 °C enhanced the inductive effect of the phosphate radical and led to the formation of a tight nanoheterogeneous interface between AgPO and AgS, thereby promoting interfacial electron transfer and reducing the recombination of photogenerated carriers.
View Article and Find Full Text PDFEvaluation of acute plant toxicity, antioxidant activity, molecular docking and bioactive compounds of lemongrass oil isolated from Omani cultivar.
Toxicol Rep
June 2025
School of Pharmacy, College of Health Sciences, University of Nizwa, Oman.
Lemongrass (Poaceae) is one of the aromatic plants with strong odors. Traditionally, lemon grass oil has been used for the treatment of many diseases such as gastrointestinal cramps, high blood pressure, high body temperatures, and fatigue, and is also considered an antibacterial and anti-diarrheal agent. Therefore, this study aims to investigate volatile active constituents and a few important biological activities of the volatile oil of lemongrass (Cymbopogon citratus) grown in Oman.
View Article and Find Full Text PDFRevolutionizing ovarian cancer therapy by drug repositioning for accelerated and cost-effective treatments.
Front Oncol
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Laboratorio de Farmacogenética, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Drug repositioning, the practice of identifying novel applications for existing drugs beyond their originally intended medical indications, stands as a transformative strategy revolutionizing pharmaceutical productivity. In contrast to conventional drug development approaches, this innovative method has proven to be exceptionally effective. This is particularly relevant for cancer therapy, where the demand for groundbreaking treatments continues to grow.
View Article and Find Full Text PDFEffective killing of biofilm by nanoemulsion delivery of plant phytochemicals.
Microbiol Spectr
January 2025
Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, USA.
Unlabelled: is an acid-fast, aerobic, non-motile, and biofilm-forming bacterium. The increasing prevalence of mycobacterial infections makes it necessary to find new methods to combat the resistance of bacteria to conventional antibiotics. is an emerging pathogen that is intrinsically drug resistant due to several factors, including an impermeable cell envelope, drug efflux pumps, target-modifying enzymes, and the ability to form thick, robust biofilms.
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