AI Article Synopsis

  • Objectives of the study were to examine the relationship between vitamin D, parathormone levels, and myocardial iron overload in patients with beta-thalassaemia major, as increased iron levels are a significant cause of death in these patients.
  • The study involved 62 beta-thalassaemia major patients, measuring key parameters like parathormone and vitamin D metabolites, along with assessing myocardial iron content using MRI and serum ferritin levels.
  • Findings indicated that 60% of patients had low vitamin D levels, and those with higher myocardial iron content also had significantly elevated parathormone levels, identifying PTH as a key predictor of iron overload.

Article Abstract

Objectives: Despite advances in conventional treatment, iron-induced cardiomyopathy is still the most frequent cause of death among patients with beta-thalassaemia major. Recent studies have correlated increased myocardial iron content to decreased levels of vitamin D in thalassaemic patients. The aim of this study was to measure parathormone (PTH) and metabolites of vitamin D and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with beta-thalassaemia major.

Methods: In 62 patients (29 M and 33 F, mean age: 22.79 +/- 6.18 yr) with beta-thalassaemia major levels of intact parathormone (iPTH) and vitamin D metabolites [25(OmicronH)D(3) and 1,25(OmicronH)(2)D(3)] were measured in serum. Additionally, estimation of myocardial iron content was performed by magnetic resonance imaging, whereas mean serum ferritin concentrations were calculated for 1 yr prior to the study.

Results: Results showed markedly decreased levels of serum 25(OH)D(3) in 37 patients (60%), whereas 7 patients (11%) had borderline 25(OH)D(3) levels (between 50 and 75 nmol/L). Serum iPTH levels were significantly higher in patients having increased myocardial iron compared to those having normal myocardial iron (44.04 +/- 22.09 pg/mL vs. 31.39 +/- 14.30 pg/mL, P = 0.017). Multivariant regression analysis identified PTH levels as the major predictor of increased myocardial iron.

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http://dx.doi.org/10.1111/j.1600-0609.2009.01349.xDOI Listing

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