A method for the synthesis of small molecule macroarrays of N-acylated L-homoserine lactones (AHLs) is reported. A focused library of AHLs was constructed, and the macroarray platform was found to be compatible with both solution and agar-overlay assays using quorum-sensing (QS) reporter strains. Several QS antagonists were discovered and serve to showcase the macroarray as a straightforward technique for QS research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175425 | PMC |
| http://dx.doi.org/10.1021/ol901871y | DOI Listing |
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