AI Article Synopsis
- Scientists studied how some cancer cells resist dying and how a substance called interferon-gamma can help make them more likely to die.
- They found that interferon-gamma makes changes in the cancer cells that help them respond better to a death signal.
- The research suggests that interferon-gamma might be a useful way to treat brain cancer by making these cells more sensitive to treatments that cause them to die.
Article Abstract
In the present study, we investigated the mechanisms of the resistance to CD95-mediated cell death and the effects of interferon-gamma in modulating the susceptibility to CD95-induced apoptosis of human astroglioma cells. We found that interferon-gamma administration sensitized cancer cells to CD95-mediated apoptosis. The mechanism underlying this sensitization appeared to be associated with a framework of cell changes, including up-regulation of death receptor at the cell surface, pro-apoptotic molecule Bax and Bak over-expression and mitochondria hyperpolarization, as is known to be associated with cell sensitization to apoptosis. An involvement of the proteasome activity in the mechanism of sensitization by interferon-gamma was also detected, probably as a result of the differing expression of catalytic proteasome subunits. Taken together, these findings suggest that interferon-gamma could represent a promising candidate for modulating astroglioma cell apoptotic susceptibility.
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| http://dx.doi.org/10.1111/j.1742-4658.2009.07271.x | DOI Listing |
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